Bone formation Flashcards

1
Q

Endochondral ossification

A

Bones of axial and appendicular skeleton,
Base of the skull

Cartilage by chondrocyte, later replaced with woven bone, and remodel to lamellar bone.

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2
Q

Woven bone occurs when

A

In adults,

after fracture and Paget’s disease

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3
Q

Membraneous ossification

A

Bones of calvarium (skull) and facial bone

Woven bone formed without cartilage
Later remodeled to lamellar bone

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4
Q

PTH

A

At low, intermittent level,
anabolic (building bone) on osteoblast, osteoclast

At chronic, high level,
catabolic (osteitis fibrosa cystica)

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5
Q

Estrogen

A

Inhibits apoptosis of osteoblasts

Induces apoptosis of osteoclasts

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6
Q

Achondroplasia

A

Failure of longitudinal bone growth
(endochondral ossification)

Constitutive FGFR3 actually inhibits chondrocyte proliferation.

> 85% sporadic mutation, associated with adv paternal age
Also autosomal dominant pattern.

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