Arachidonic acid

Question 1

Lipoxygenase pathway

Answer 1

Leukotrienes

Question 2

LTC4, D4, and E4

Answer 2

Bronchoconstriction, vasoconstriction, smooth muscle constriction, and increased vascular permability

Question 3

LTB4

Answer 3

neutrophil chemotatic agent

Question 4

PGI2

Answer 4

inhibits platelet aggregation
promotes vasodilation

Platelet gathering inhibitor

Question 5

Aspirin

Answer 5

Both COX1/2, acetylate
Increase bleeding time, but no effect of PT/PTT

Low dose (<300): inhibit platelet aggregation
Mid dose (300-2400): anti fever and analgesic
High dose (2400-4000): anti inflammatory

Toxicity: tinnitus
Stimulates hyperventilation and resp alkalosis

Question 6

NSAIDS

Answer 6

Both COX1/2
Renal ischemia
(PG vasodilates afferent arteriole)

Question 7

COX2 inhibitor

Answer 7

Spares platelet function as THA2 production is dependent on COX2

Use: RA, osteoarthritis, pts with gastritis or ulcers
Toxicity: increased risk of thrombosis, sulfa allergy

Question 8

Acetaminophen

Answer 8

Reversibly inhibit COX, in CNS
Inactivated peripherally

USe: anti pyretic, analgesic, but not anti inflam

Question 9

Bisphosphonate

Answer 9

Alendronates or other dronates

Pyrophosphate analog, which binds hydroxyapatide in bone
Inhibiting osteoclast activity

USE: osteoporosis, hypercalcemia, Paget’s disease of bone

Toxicity: corrosive esophagitis, osteonecrosis of jaw