Arachidonic acid Flashcards

1
Q

Lipoxygenase pathway

A

Leukotrienes

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
2
Q

LTC4, D4, and E4

A

Bronchoconstriction, vasoconstriction, smooth muscle constriction, and increased vascular permability

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
3
Q

LTB4

A

neutrophil chemotatic agent

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
4
Q

PGI2

A

inhibits platelet aggregation
promotes vasodilation

Platelet gathering inhibitor

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
5
Q

Aspirin

A

Both COX1/2, acetylate
Increase bleeding time, but no effect of PT/PTT

Low dose (<300): inhibit platelet aggregation
Mid dose (300-2400): anti fever and analgesic
High dose (2400-4000): anti inflammatory

Toxicity: tinnitus
Stimulates hyperventilation and resp alkalosis

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
6
Q

NSAIDS

A

Both COX1/2
Renal ischemia
(PG vasodilates afferent arteriole)

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
7
Q

COX2 inhibitor

A

Spares platelet function as THA2 production is dependent on COX2

Use: RA, osteoarthritis, pts with gastritis or ulcers
Toxicity: increased risk of thrombosis, sulfa allergy

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
8
Q

Acetaminophen

A

Reversibly inhibit COX, in CNS
Inactivated peripherally

USe: anti pyretic, analgesic, but not anti inflam

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
9
Q

Bisphosphonate

A

Alendronates or other dronates

Pyrophosphate analog, which binds hydroxyapatide in bone
Inhibiting osteoclast activity

USE: osteoporosis, hypercalcemia, Paget’s disease of bone

Toxicity: corrosive esophagitis, osteonecrosis of jaw

How well did you know this?
1
Not at all
2
3
4
5
Perfectly