Goodpasture's syndrome

Question 1

What is Goodpasture’s syndrome?

Answer 1

Autoimmune disorder with antibodies generated to components of the glomerular basement membrane, affecting the kidneys and the lungs

Question 2

Describe the pathophysiology of Goodpasture’s syndrome

Answer 2

Antibodies against alpha-3 subunit of type IV collagen produce a type II hypersensitivity reaction

Question 3

What are some predisposing factors of Goodpasture’s syndrome?

Answer 3

• Association with HLA-DR2
• Exposure to organic solvents or hydrocarbons
• Smoking
• Infection, e.g. influenza A2
• Cocaine inhalation
• Exposure to metal dusts

Question 4

What are some non-specific symptoms of Goodpasture’s syndrome

Answer 4

malaise, weight loss, fatigue, fever, chills, arthralgia

Question 5

What are some lung symptoms of Goodpasture’s syndrome?

Answer 5

haemoptysis, chest pain, cough, SOB

Question 6

What are some kidney symptoms of Goodpasture’s syndrome?

Answer 6

haematuria, proteinuria, oedema, high urea in blood, hypertension

Question 7

What investigations are required in Goodpasture’s syndrome?

Answer 7

• Bloods - anti-GBM antibodies
• Renal biopsy - glomerulonephritis

Question 8

How is Goodpasture’s syndrome managed?

Answer 8

Plasmapheresis