Goldstien Peds Flashcards

1
Q

Risk factors for acute hematogenous osteomyelitis (6)

A
  • Diabetes
  • Chronic renal disease
  • Hemoglobinopathies
  • Rheumatoid arthritis
  • Concurrent varicella infection
  • Immunocompromise
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2
Q

Osteomyelitis differential diagnosis (11)

A
  • Thrombophlebitis
  • Bone infarction
  • Sickle cell crisis
  • Cellulitis
  • Rheumatic fever
  • Septic arthritis
  • Fracture
  • Toxic synovitis
  • Caffey’s disease
  • Gaucher’s disease
  • Malignancy (including leukemia)

(V.I.T.I.M.N. – vascular, infectious, trauma, inflammatory, metabolic, neoplastic)

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3
Q

Indications for surgical treatment of osteomyelitis (3)

A
  • Aspiration of pus
  • Imaging findings of an abscess or sequestrum
  • Failure of non-surgical management
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4
Q

Indications for step-down from parenteral to oral antibiotics in osteomyelitis treatment (5)

A
  • No fever
  • Normal use of the limb
  • Local inflammation subsided
  • Able to tolerate oral antibiotics
  • Improving serologic markers
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5
Q

Complications of pediatric osteomyelitis (9)

A
  • Meningitis
  • Chronic osteomyelitis
  • Septic arthritis
  • Septicaemia
  • Limb-length discrepancy
  • Angular deformity
  • Pathologic fracture
  • Gait abnormality
  • Venous thromboembolism
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6
Q

Factors leading to subacute presentation of osteomyelitis (3)

A
  • Increased host resistance
  • Less virulent organism
  • Prior antibiotic exposure
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7
Q

Classification of subacute osteomyelitis (6)

A
  • IA/B: bony lucency
  • II: metaphyseal with cortical bone loss
  • III: diaphyseal
  • IV: presence of onion skinning
  • V: epiphyseal
  • VI: spine
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8
Q

Classification of cerebral palsy (2)

A

- Physiologic

o Spastic – increased muscle tone, hyperreflexia (#1)

o Athetoid – slow, writing involuntary movements

o Ataxic – inability to coordinate muscles for voluntary movement

o Mixed- A
-anatomic

Hemiplegic – unilateral UE/LE

o Diplegic – LE > UE, strabismus, IQ may be normal

o Quadriplegic – all 4 extremities, low IQ

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9
Q

Predictors of walking in CP (5)

A

- Positive

o Sitting by age 2

o Pulling to stand by age 2

- Negative

o Persistence of ≥ 2 primitive reflexes by age 1

o Not sitting by 5 years

o Not walking by 8 years

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10
Q

Grading of CP with the Gross Motor Function Classification System (5)

A
  • Level I: walks and runs, does stairs independently
  • Level II: walks with no aids, stairs with railing
  • Level III: walks with aids as a primary method of travel
  • Level IV: stands, uses wheelchair independently (manual/motor)
  • Level V: wheelchair powered by caregiver
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11
Q

Treatment options for cerebral palsy (4)

A
  • Physiotherapy (ROM, stretching, strengthening)
  • Tone reduction (medications for spasticity control, Botox)
  • Bracing/orthotics
  • Serial casting
  • Surgery
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12
Q

Surgical options for elbow flexion contracture in CP (3)

A
  • Musculocutaneous neurectomy
  • Biceps lengthening
  • Brachialis lengthening
  • lacertus fibrosis release
  • brachioradialis origin release
  • pronator teres release
  • transfer of the FCU to the ECRB
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13
Q

Goals of surgical treatment of GMFCS I-III CP (4)

A
  • Optimize gait efficiency

o Decrease energy expenditure

o Increase physical function

o Increase activity participation

  • Improve gait cosmesis
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14
Q
  1. Requirements for successful ambulation in children with CP (5)
A
  • Stability in stance phase
  • Clearance in swing phase
  • Preposition of foot at initial contact
  • Adequate step length
  • Optimal energy consumptions
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15
Q

Classification of scoliosis in cerebral palsy (4)

A

Weinstein classification
Group I - double curves with thoracic and lumbar component and minimal pelvic obliquity

Group II - large lumbar or thoracolumbar curves with marked pelvic obliquity

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16
Q

Indications for surgery for scoliosis in CP (3)

A
  • Progressive deformity (> 45-50°)
  • Sitting imbalance
  • Pelvic obliquity
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17
Q

Principles of surgery for scoliosis in CP (4)

A
  • Pre-op nutrition assessment ± g-tube
  • Posterior spinal fusion
  • Segmental instrumentation
  • Include the pelvis (if non-ambulatory)
18
Q

Classification of hip disorders in CP (3)

A
  • Hip at risk – abduction < 45° with partial uncovering

reimers index <30

  • Hip subluxation - reimers index >30
  • Spastic dislocation - RI >100
  • windswept
19
Q

Gait problems in CP (3)

A
  • Equinus gait
  • Jump gait
  • Crouched gait
  • Stiff-knee gait
20
Q

Risk factors for myelodysplasia (4)

A
  • Maternal hyperthermia
  • Maternal diabetes
  • Valproic acid/carbamazepine
  • Maternal folate deficiency
21
Q

Classification of myelodysplasia (4)

A
  • Spina bifida occulta
  • Meningocele
  • Myelomeningocele
  • Rachischisis
22
Q

Things to remember about scoliosis in myelodysplasia (6)

A
  • Bracing ineffective
  • May need anterior spinal fusion due to deficient posterior elements (pre-op 3D CT)
  • Check shunt prior to surgery
  • Pre-op MRI to rule out Chiari II malformation/tethered cord
  • Latex allergy
  • Higher risk of pseudarthrosis/infection
23
Q

Classification of spinal muscular atrophy (3)

A

- Type I

o Acute Werdnig-Hoffman

o < 6 months

o Death by 2 years

- Type II

o Chronic Werdnig-Hoffman

o 6-24 months

o May live into 40’s

- Type III

o Kugelberg-Welander disease

o 2-10 years

o Best prognosis

24
Q

Classification of osteogenesis imperfecta (Sillence) (4)

A
  • Type I:

o Autosomal dominant

o Blue sclera

o Hearing loss

 A – teeth involved

 B – teeth normal

  • Type II:

o Autosomal recessive

o Blue sclera

o Lethal in utero

  • Type III:

o Autosomal recessive

o Normal sclera

o # at birth with progressive short stature

  • Type IV:

o Autosomal dominant

o Blue sclera

 A – teeth involved

 B – teeth normal

25
Q

Histologic findings of osteogenesis imperfecta (6)

A
  • Increased diameter of haversian canals
  • Increased size of osteocyte lacunae
  • Increased number of cells
  • Replicated cement lines
  • Decreased number of trabeculae
  • Decreased cortical thickness
26
Q

Outcomes of bisphosphonate treatment of osteogenesis imperfecta (3)

A
  • Increased cortical thickness
  • Decreased fracture rates
  • Decreased pain
27
Q

Methods of classifying skeletal dysplasias (5)

A
  • Proportionate vs. disproportionate
  • By bone segment involved

o Rhizomelic – proximal

o Mesomelic – middle

o Acromelic – distal

  • By bone involved
  • By causative gene defect
  • By presence or absence of spine involvement
28
Q

Disorders of the primary ossification centre (3)

A
  • Cleidocranial dysplasia
  • Apert’s syndrome
  • Proximal femoral focal deficiency
  • (C.A.P.)
29
Q

Disorders of the secondary ossification centre (4)

A
  • Diastrophic dysplasia
  • Spondyloepiphyseal dysplasia congenital
  • Spondyloepiphyseal dysplasia tarda
  • Multiple epiphyseal dysplasia
  • (D.S.M.)
30
Q

Disorders of hypertrophic zone

A
  • psudoachondroplasia
  • Mucopolysaccharidoses

o Morquio’s

o Hurler’s

o Hunter’s

o San Filippo’s

  • Enchondroma
  • Rickets
  • SCFE
31
Q

Types of Rickets (5)

A
  • Vitamin D dependent
  • Vitamin D resistant (hypophosphatemic)
  • Vitamin D deficient (nutritional)
  • Renal
  • Gastrointestinal
32
Q

Disorders of osteoid production (2)

A
  • Osteogenesis imperfecta
  • Scurvy
33
Q

Disorders of bone remodeling (7)

A
  • Metaphyseal dysplasia(s)
  • Osteopetrosis
  • Gaucher’s disease
  • Osteopathia striata
  • Pyknodysostosis
  • Melorrheostosis
  • Osteopoikilosis
34
Q

Disorders of FGFR3 (3)

A
  • Hypochondroplasia
  • Achondroplasia (#1)
  • Thanatophoric dysplasia
  • (H.A.T. – there are “3” disorders of FGFR3)
35
Q

Functions of fibroblast growth factors (5)

A
  • Cell induction/differentiation
  • Cell growth/migration
  • Bone growth
  • Angiogenesis
  • Wound healing
36
Q

Disorders of collagen oligomeric matrix protein (COMP) (2)

A
  • Pseudoachondroplasia
  • Multiple epiphyseal dysplasia
37
Q

Disorder of parathyroid hormone-related peptide (1)

A
  • Jansen’s metaphyseal chondrodysplasia
  • (“Dwarves of stone (↑ Ca2+) stand alone”)
38
Q

Differential diagnosis of Caffey’s disease (infantile cortical hyperostosis) (4)

A
  • Child abuse/trauma
  • Infection
  • Scurvy
  • Progressive diaphyseal dysplasia
39
Q

Disorders of collagen (9)

A
  • Osteogenesis imperfecta (COL1)
  • Ehlers-Danlos syndrome (COL1/3/5)
  • Achondrogenesis (COL2)
  • Spondyloepiphyseal dysplasia congenital (COL2)
  • Spondyloepiphyseal dysplasia tarda (SEDL/TRAPPC2)
  • Kniest dysplasia (COL2)
  • Precocious arthritis (COL2)
  • Stickler syndrome (COL2/11)
  • Schmidt metaphyseal chondrodysplasia (COL10)
40
Q

Disorders associated with structural protein deficits (9)

A
  • Achondroplasia
  • Pseudoachondroplasia
  • Multiple epiphyseal dysplasia
  • Spondyloepiphyseal dysplasia congenital
  • Kniest dysplasia
  • Stickler syndrome
  • Schmidt’s metaphyseal chondrodysplasia
  • Ehler’s Danlos syndrome
  • Marfan’s syndrome
  • Osteogenesis imperfecta