Glomerular disease I Flashcards
glomerulonephritis symptoms
- edema (extracellular volume expansion)
- gross hematuria
glomerulonephritis signs
- hematuria
- lipiduria
- some proteinuria
- renal failure
what are the RBC signs that point to glomerular origin in glomerulonephritis?
- RBC casts
- dysmorphic RBCs (blebs)
what are the three major findings on biopsy for asymptomatic hematuria?
- normal
- thin basement membrane nephropathy
- IgA nephropathy
how does IgA nephropathy present?
- symptomatic hematuria with proteinuria
- macroscopic hematuria associated with URTI
- henoch-schonlein purpura
pathologically, rapidly progressive glomerulonephritis is characterized by the presence of __________**
cellular crescents
what makes up the crescents in rapidly progressive glomerulonephritis?
proliferation of parietal epithelial cells
what are the 3 broad causes / categories of rapidly progressive glomerulonephritis?
- direct Ig attack
- immune complex deposition
- pauci-immune
direct Ig attack in rapidly progressive glomerulonephritis (goodpasture disease) is made up of antibodies against what component? what are the IF findings?
- anti-GBM Abs
- linear deposits of IgG in GBM
what is the IF pattern with immune complex deposition in rapidly progressive glomerulonephritis?
granular
what is the most common cause of ACUTE glomerulonephritis worldwide?
post infectious glomerulonephritis
what is the pathophysiology of post infectious glomerulonephritis?
in situ immune complex formation due to glomerular deposition of strep nephritic antigens
what is the EM pattern of post infectious glomerulonephritis?
subepithelial electron dense deposits
what are the pulmonary-renal syndromes?
- anti GBM disease (goodpasture)
- systemic vasculitis
- lupus
- other forms of glomerulonephritis
what immunoglobins are present in class III/IV lupus nephritis?
IgG IgA IgM C3 C1q
