Benign prostate disease Flashcards
what are the anatomical zones of the prostate?
- transitional
- central
- peripheral
- anterior fibromuscular stroma
BPH affects which zone?
transition zone
which zone gives rise to 70% of cancers?
peripheral zone
the transition zone houses which main dysfunction?
BPH
the peripheral zone houses which main dysfunction?
70% of cancers
is hematuria associated with BPH?
yes
LUTS
lower urinary tract symptoms
what is the american urological association symptom score index (AUASI)? what are the severity scores?
- standardized questionnaire to assess quality of life for patients with BPH
- mild
- moderate
- severe
how is the decision to treat BPH determined?
- patient’s level of bother
- willingness / ability to comply with therapy
what drugs are used for BPH?
- alpha blockers
- 5a reductase inhibitors
- combination therapy
prostate and bladder neck smooth muscle tone is mediated by what type of adrenergic receptors?
alpha
what is the prominent receptor type in the prostate and bladder neck?
a1A
vascular smooth muscle has what type of adrenergic receptor?
a1B
which drug class stops disease progression in BPH?
5a reductase
what are the 5a reductase inhibitor medications?
- finasteride
- dutasteride
