Gestational Trophoblastic Disorders

Question 1

Name the 3 gestational trophoblastic disorders.

Answer 1

1. Complete hydatiform mole
2. Partial hydatiform mole
3. Choriocarcinoma

Question 2

How is a hydatiform mole produced?

Answer 2

An empty egg is fertilized by a single sperm and then duplicates. All 46 chromosomes are of paternal origin.

Question 3

What are some features of a hydatiform mole?

Answer 3

• bleeding in first or early second trimester
• Exaggerated symptoms of pregnancy e.g. hyperemesis
• Uterus large for dates
• Very high serum levels of human chorionic gonadotropin (hCG)
• Hypertension and hyperthyroidism* may be seen
  
  • HCG can mimic TSH

Question 4

What will 2-3% oc hydatiform moles become?

Answer 4

choriocarcinoma