Genetics and Health Week 12 Flashcards

1
Q

What is the difference between somatic cell gene therapy

and Germline Gene Therapy

A

Somatic Cell Gene Therapy: Transfer of genes into the somatic cells of the patient, such as cells of the bone marrow, new DNA does not enter eggs or sperm

Germline Gene Therapy: DNA is transferred into cells that produce reproductive cells, eggs or sperm in the body

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2
Q

Mechanical Vectors for Gene Therapy

A

Liposomes: through fusions
Microprojectiles: through injections

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3
Q

How does antiRNA inhibit gene expression

A

Introduce siRNA to cleavage the target mRNA, leading to a loss of protein synthesis
The expression of the target gene is silenced

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4
Q

What are the three gene therapy approaches

1) Ex vivo
2) In Situ
3) In vivo

A

1) Target cells are removed from the body and reinserted into the body
2) Virus is targeted to the cell we wanted to be in

3) Reintroduce the DNA by the blood
Travel to the site and affect those cells
And those cells will starting producing

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