Genetic Locations of Diseases

Question 1

Genes associated with dyslexia

Answer 1

DCDC2
DYX1C1
KIAA0319
GCFC2
MRPL19
ROBO1

Question 2

Genes associated with schizophrenia

Answer 2

DTNBP1 (dysbindin) - chromosome 6 (6p 22.3)
COMT - chromosome 22
NRG1(neuregulin 1) - chromosome 8 (8p 21-22)
G72 - chromosome 13
RGS4 - chromosome 1
DAOA - chromosome 13
DISC1 - chromosome 1
DRD2 - chromosome 11

Question 3

Genes associated with ASD

Question 4

Genes associated with alcohol excess

Question 5

Genes associated with Early Onset Alzheimer’s

Answer 5

PSEN1 (presenilin-1) [14]
PSEN2 (presenilin-2) [1]
APP (amyloid precursor protein) [21]
ApoE (apolipoprotein E) [19]

PSEN 1 = 30-70%
PSEN 2 = 5%
APP = 10-15%

Question 6

Genes associated with Late Onset Alzheimer’s

Answer 6

APOE 4 - 19

Question 7

Genes a/w familial FTD

Answer 7

C9orf72 [9]
PGRN (progranulin) [17]
MAPT (tau) [17]

Question 8

Genes a/w Huntington’s

Answer 8

HTT (aka IT15) (huntingtin) [4]

Question 9

Genes a/w CADASIL

Answer 9

Notch3 (notch 3) [19]

Question 10

Genes a/w LBD

Answer 10

APOE [19]
GBA [1]
SNCA [4]