GEN BIO - Cell Cycle Flashcards
series of events that takes place in a cell as it grows and divides
CELL CYCLE
two major phases of cell cycle
Interphase and Mitotic phase (M-phase)
Highly regulated process
CELL CYCLE
cells undergoes normal growth processes and there is a replication of DNA and other organelles
INTERPHASE
When the cell spends most of its
time, it is called _____.
Longest Phase
In resting phase, the cell is at rest but ____________.
Metabolically active
The largest phase in which 95% of growth occurs.
INTERPHASE
The cell is growing, copying it’s DNA and preparing for division
INTERPHASE
The copying of DNA is called
synthesis or replication
Three stages of interphase:
⚬ G1 (Gap1 Phase/ Growth 1 phase)
⚬ S (Synthesis Phase)
⚬ G2 (Gap2 Phase/ Growth 2 phase)
the cell increases in size, make new set of organelles, protein
synthesis
G1 Phase
3 Major Checkpoints
- G1 checkpoint
- G2 checkpoint
- M-checkpoint
(metaphase checkpoint
or spindle checkpoint )
known as the restriction
point
Cell Cycle Checkpoints
Verify whether all the cellular activities are accurately completed at each stage of interphase
Cell Cycle Checkpoints
The main decision point for a cell – that is, the primary point at which it must choose whether or not to divide.
G1 Checkpoint
G1 Checkpoint is located at _____________.
the end of the cell cycle’s G1 phase,
G1 Checkpoint is called a restriction point for ____________.
ANIMAL CELL
G1 Checkpoint is called a start point for ____________.
YEAST CELLS
Check growth condition depends on:
- CELL SIZE
- NUTRIENTS
- DNA INTEGRITY
- MOLECULAR SIGNALS
Longest and the most essential stage of interphase
SYNTHESIS PHASE
The cell replicates its DNA
SYNTHESIS PHASE
The DNA double helix is unzipped completely by an enzyme called
HELICASE
One DNA nucleotide at a time is added to BOTH sides of the DNA strand With the help of another enzyme called DNA
POLYMERASE
The cell continues to grow and synthesize proteins while preparing for cell division.
G2 Phase
Reorganize cell organelles and DNA condensation
G2 Phase
Determine state of pre-mitotic
cell
G2 Checkpoint
Ensure that all the chromosomes have been replicated and that the replicated DNA is not damaged
G2 Checkpoint
identify a replication faults
G2 Checkpoint