GEN BIO 1.3 Flashcards
THE LIFE OF A CELL
CELL CYCLE
series of events that takes place in a cell as it grows and divides.
CELL CYCLE
Highly regulated process
CELL CYLE
TWO MAJOR PHASES OF CELL CYCLE
interphase and mitotic phase (M-phase)
cells undergoes normal growth processes and there is a replication of DNA and other organelles .
INTERPHASE
cell spends most of its
time
LONGEST PHASE
the cell is at rest but metabolically active
RESTING PHASE
The largest phase in which 95% of
growth occurs
INTERPHASE
This is the time between cell
divisions
INTERPHASE
The cell is growing, copying itβs
DNA and preparing for division
INTERPHASE
The copying of DNA is called
SYNTHESIS OR REPLICATION
Before the cell moves from interphase to mitotic phase, there is a series of cell _________ to ensure that every component of the cell must meet the needed requirements
CHECKPOINTS
THREE STAGES OF INTERPHASE
- G1 (Gap1 Phase/ Growth 1 phase)
- S (Synthesis Phase)
- G2 (Gap2 Phase/ Growth 2 phase)
the cell increases in size, make new set of organelles, protein
synthesis
G1 PHASE
3 Major Checkpoints
- G1 checkpoint
- G2 checkpoint
- M-checkpoint
(metaphase checkpoint
or spindle checkpoint )
verify whether all the cellular activities are accurately completed at each stage of interphase
CELL CYCLE CHECKPOINTS
known as the restriction
point
CELL CYCLE CHECKPOINTS
is the main decision point for a cell β that is, the primary point at
which it must choose whether or not to divide.
G1 CHECKPOINT
first checkpoint which is located at the end of the cell cycleβs G1 phase
G1 CHECKPOINT
it is called a restriction point for animal cells and start point for yeast cells
G1 CHECKPOINT
- cellsβ size
- nutrients
- DNA integrity
- molecular signals
G1 CHECKPOINT
many cells stop at this stage and enter a resting state called G0
G1 CHECKPOINT
longest and the most essential
stage of interphase
SYNTHESIS PHASE
The cell replicates its DNA
SYNTHESIS PHASE
The cell continues to grow
and synthesize proteins while preparing for cell division.
G2 PHASE
It also checks for any DNA damage and repairs it to ensure that the cellβs genetic material is intact and
ready for division
G2 PHASE
Reorganize cell organelles
and DNA condensation
G2 PHASE
determine state of pre-mitotic
cell
G2 CHECKPOINT
ensure that all the chromosomes have been replicated and that the
replicated DNA is not damaged
G2 CHECKPOINT
identify a replication faults
G2 Checkpoint
the cell prepares for division and
checks for errors
G2 Checkpoint
DNA integrity and DNA replication
G2 Checkpoint
If the checkpoint mechanisms detect problems with the DNA, the cell cycle is halted, and the cell attempts to either complete DNA replication or repair the damaged DNA.
TRUE
If damage cannot be repaired, _______ or programmed cell
death occurs to ensure that the damage DNA is not passed on the daughter cells and important in preventing cancer.
APOPTOSIS
the cell undergoes different stages
namely prophase, metaphase, anaphase, and telophase. For every stage, there is a unique characteristic to distinguish one phase to another
MITOTIC PHASE
follows the mitosis phase, where
cytoplasm divides.
CYTOKINESIS
occurs near the end of the
metaphase stage of karyokinesis
M Checkpoint (metaphase checkpoint or spindle checkpoint)
ensure proper spindle assembly
and correct attachment to centromeres (prevents nondisjunction events)
M Checkpoint (metaphase checkpoint or spindle checkpoint)
If a chromosome is misplaced, the cell will pause mitosis,
allowing time for the spindle to
capture the stray chromosome.
M Checkpoint (metaphase checkpoint or spindle checkpoint)
It is a fundamental process to create life, occurring in all forms of it, ensuring the perpetuity of their existence, as well as growth,
tissue replacement/repair, and reproduction in multicellular organisms
CELL DIVISION
happens when a parent cell divides into two or more cells called daughter cells.
CELL DIVISION
Parent cells are diploid and make 2
daughter cells that are also diploid with their own new nuclei.
CELL DIVISION
________ means 2 of each chromosome: 2 (n)= 2 (23) = 46
chromosomes
DIPLOID
Living things grow because each cell increases in size.
FALSE because they grow by producing more cells
Cell division repairs damaged tissue
TRUE
If cell gets too big, it cannot get enough nutrients into the cell andwastes out ofthe cell
TRUE
located in the nucleus and controls all cell activities including cell
division
DNA
Long and thread-like DNA in
a non-dividing cell is called
chromatin
Doubled, coiled, short DNA
in a dividing cell is called
chromosome
Every organism has the same number of chromosomes.
FALSE because Every organism has its own specific number of
chromosomes.
All somatic (body) cells in an organism have the same kind and number of chromosomes
Examples:
* Human=46chromosomes
* Humanskincell =46 chromosomes
* Humanheart cell
* 46 chromosomes
* Human muscle cell = 46chromosomes
CHROMOSOME NUMBER
Many organisms, especially
unicellular organisms, reproduce
by means of cell division β called
asexual reproduction
BINARY FISSION
occurs in all the somatic (body) cells and is the process by which a single cell divides into two
MITOSIS (KARYOKINESIS)
Who discovered Mitosis?
Walther Flemming
Function:Growth and Repair, Cell reproduction
MITOSIS
phases of cell cycle
I Peed on the MAT. See?
Interphase > Prophase > Metaphase > Anaphase >Telophase > Cytokinesis
STAGES OF MITOSIS
- Early Prophase
- Mid Prophase
- Late Prophase
- Metaphase
- Anaphase
- Telophase
- Cytokinesis
Centrioles move to each pole of
the cell
EARLY PROPHASE
Chromosomes appear as long,
thin threads
EARLY PROPHASE
The nucleolus becomes less
distinct
EARLY PROPHASE
The nuclear membrane is still
visible
EARLY PROPHASE
Centrioles begin to organize
spindle fiber
MID PROPHASE
Sister chromatids are formed with a centromere as their point of attachment
MID PROPHASE
Centrioles are nearly at the
opposite sides of the nucleus
LATE PROPHASE
The nuclear membrane slowly
disintegrates
LATE PROPHASE
Chromosomes move toward the
equator
LATE PROPHASE
the chromatin in the nucleus condenses and coiled up into visible chromosomes, which become visible under a microscope.
MITOSIS: PROPHASE
The centrosome duplicates, and each one moves to one of the cellβs ends, where spindle fibers are formed.
MITOSIS: PROPHASE
Chromosomes can be seen as two
chromatids, inthe shape of an βXβ
PROPHASE
Nuclear envelope dissolves
PROPHASE
Centrioles are present with some
spindle fibers
PROPHASE
46 chromosomes
PROPHASE
The nuclear envelope /membrane breaks down, allowing the spindle fibers to attach to the chromosomes.
MITOSIS: PROPHASE
Chromosomes line up in middle of cell
MITOSIS: METAPHASE
Spindle fibers connect to chromosomes
MITOSIS: METAPHASE
The nuclear membrane has completely disappeared
MITOSIS: METAPHASE
The centromere of each double-stranded chromosome is attached to a spindle fiber at equator
MITOSIS: METAPHASE
Centrioles are already at opposite ends of the poles
MITOSIS: METAPHASE
The chromosomes line up at the center of the cell forming the metaphase plate
MITOSIS: METAPHASE
Chromosomes line up in the middle
METAPHASE
Nuclear envelope is gone (no
nucleus)
METAPHASE
Spindle fibers (on opposite poles)
are stretching towards the chromosomes
METAPHASE
46 chromosomes
METAPHASE
Chromosome copies divide and
moves to the opposite pole
MITOSIS: ANAPHASE
Spindle fibers pull chromosomes to
opposite poles
MITOSIS: ANAPHASE
Sister chromatids start to move
toward the poles, seemingly being
pulled by the thread or fibers
MITOSIS: ANAPHASE
Spindle fibers pull chromosomes
towards the separate poles
ANAPHASE
Chromosomes are split in HALF
ANAPHASE
Sister chromatids are now their OWN chromosome
ANAPHASE
The cell elongates due to action of the spindle fibers
ANAPHASE
92 chromosomes
ANAPHASE
Chromosomes uncoil
MITOSIS: TELOPHASE
Nuclear envelopes form
MITOSIS: TELOPHASE
2 new nuclei are formed
MITOSIS: TELOPHASE