Gastroenterology by Dr Cintia Flashcards
Diseases of the Small and Large Intestines
Crohn Dx CLINICAL FEATURES
- Pain is more common, affects all colon except for rectum, skip lesions, transmural inflammation, causes fistulas, fissures, noncaseating granulomas, perianal disease.
Crohn Dx FIRST INVESTIGATION
-Stool sample faecal calprotectin (Neutrophil derived biomarker)
-CXR, AXR to see complications of peritonitis or toxic megacolon.
Crohn Dx BEST INVESTIGATION
- Biopsy (Cobblestone sign)
- MRI for perianal dx in Crohn.
Crohn Dx TREATMENT
1.Mild Crohn: Budesonide enteric- coated.
2.Diffuse Crohn: Oral Prednisolone.
3.Methotrexate
4.Azathioprine - Infliximab good for Crohn w/ perianal fistula
Ulcerative Colitis CLINICAL FEATURES
- Bleeding is more common, only affects the mucosa, but all the colon with rectal involvement, loss of haustra, crypt abscesses and ulcers, can cause toxic megacolon, perforation, Assoc w Primary sclerosing cholangitis
Ulcerative Colitis BEST INVESTIGATION
- Biopsy
Ulcerative Colitis TREATMENT
- Mesalazine/Sulfasalazine (Rectal+Oral preparation)
- Add Steroids (Budesonide, hydrocortisone, prednisolone rectally.
- Add Steroids orally (Prednisolone) Methotrexate and sulfasalazine cause oligospermia. But sulfasalazine is safe
to use in pregnancy and methotrexate not
syndrome diaphragmatic hernias
diaphragmatic hernia: Acquired
Congenital Malabsorption
Coeliac disease
Lactose intolerance
Diseases of the liver
Liver Function Test
Jaundice
drug-induced liver injury: Khat herbal leaves
Fatty liver (hepatic steatosis) Non-alcoholic fatty liver disease
Non-alcoholic steatohepatitis
Alcoholic hepatitis CLINICAL FEATURES
- Marked neutrophilia, fever, hepatic pain, tenderness, encephalopathy
Alcoholic hepatitis FIRST INVESTIGATION
- Inc AST>ALT, GGT
Alcoholic hepatitis TREATMENT
If encephalopathy->Prednisolone.
If CI (untreated inf)-> Oxpentifylline (CI in allergy to caffeine or theophylline)
alcoholic liver disease
Autoimmune hepatitis CLINICAL FEATURES
- Cx by infliximab, nitrofurantoin, minocycline