Gastric/Stomach CA Flashcards
Gastric CA is 2nd most common tumor in the world. T or F?
True
What 3 countries is Gastric CA particularly high in?
- China, Japan, and Korea
Which socioeconomic group is Gastric CA more common in?
lower socioeconomic group
Gastric CA is more responsible for what % of all deaths in Canada?
3%
Gastric CA is 2nd leading cause of CA _____ worldwide
mortality
Etiology (4)
- genetic factors
- carcinogenic factors in diet
- autoimmune gastritis
- chronic infection w/ H. Pylori.
Are incidence declining in Canada? How?
Yes
D/t improved storage of food w/ decr. consumption in salted, smoked, and preserved food
Examples of carcinogen factors
N-nitroso compounds and benzopyrene found in smoked and preserved foods
What is a cofactor of some gastric carcinomas? How?
chronic infections w/ h. pylori.
causes gastritis–>atrophy–>intestinal metaplasia–> and carcinomas
Patho: Between ___%-___% of gastric CA occur in what areas ? Why?
50-60% occur in the pyloric region or adjacent to the antrum
B/C
o Concentrically shaped
o gastric cancers tend to be larger
o irregularly shaped and irregular margins
describes the symptoms
- asymptomatic until late in course
- symptoms are usually vague
and non-specific - early detection is difficult
Manifestations
- symptoms are vague and include: Indigestion, anorexia, weight loss, vague epigastric pain, vomiting, and an abdominal mass
Diagnosis:
- barium x-ray
- endoscopic studies w/ biopsy
- cytologic studies of gastric secretions eg Papanicolaou smear (done routinely)
- CT and endoscopic U/S to note the spread of CA
treatment
- depends on location and extent
- sx eg radical subtotal gastrectomy
- irradiation and chemo (not useful as primary tx)
What purpose do the treatment have?
for palliative care and control metastatic spread of diease
