Gastric/Stomach CA Flashcards
Gastric CA is 2nd most common tumor in the world. T or F?
True
What 3 countries is Gastric CA particularly high in?
- China, Japan, and Korea
Which socioeconomic group is Gastric CA more common in?
lower socioeconomic group
Gastric CA is more responsible for what % of all deaths in Canada?
3%
Gastric CA is 2nd leading cause of CA _____ worldwide
mortality
Etiology (4)
- genetic factors
- carcinogenic factors in diet
- autoimmune gastritis
- chronic infection w/ H. Pylori.
Are incidence declining in Canada? How?
Yes
D/t improved storage of food w/ decr. consumption in salted, smoked, and preserved food
Examples of carcinogen factors
N-nitroso compounds and benzopyrene found in smoked and preserved foods
What is a cofactor of some gastric carcinomas? How?
chronic infections w/ h. pylori.
causes gastritis–>atrophy–>intestinal metaplasia–> and carcinomas
Patho: Between ___%-___% of gastric CA occur in what areas ? Why?
50-60% occur in the pyloric region or adjacent to the antrum
B/C
o Concentrically shaped
o gastric cancers tend to be larger
o irregularly shaped and irregular margins
describes the symptoms
- asymptomatic until late in course
- symptoms are usually vague
and non-specific - early detection is difficult
Manifestations
- symptoms are vague and include: Indigestion, anorexia, weight loss, vague epigastric pain, vomiting, and an abdominal mass
Diagnosis:
- barium x-ray
- endoscopic studies w/ biopsy
- cytologic studies of gastric secretions eg Papanicolaou smear (done routinely)
- CT and endoscopic U/S to note the spread of CA
treatment
- depends on location and extent
- sx eg radical subtotal gastrectomy
- irradiation and chemo (not useful as primary tx)
What purpose do the treatment have?
for palliative care and control metastatic spread of diease
What is the treatment of choice
sx in the form of radical subtotal gastrectomy
