gastric cancer Flashcards

1
Q

intestinal gastric cancer

A

assoc with H.pylori

commonly on lesser curvature of stomach

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2
Q

diffuse gastric cancer

A

not asoc with h.pylori

assoc with signet cells

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3
Q

Menetrier’s disease

A

pre-cancerous
hyperpplasia of gastric mucosa
assoc with parietal cell atrophy

reduced stomach acid - achlorydria

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4
Q

Krukenberg tumour

A

‘signet ring tumour’

secrete mucin, readily metastasise to ovaries

abdo bloating, ascites, dyspareunia

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5
Q

Sister Mary Joseph nodule

A

S/c peri-umbilical metastasis assoc with intestinal type gastric cancer

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6
Q

Linitis Plastica

A

muscles of stomach become thicker –> stomach holds less food

assoc with diffuse stomach cancer

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7
Q

risk factors

A
smoking 
pernicious anaemia 
H.pylori 
alcohol
dierty nitrosamines
atrophic gastritis
adenomatous polyps 
achloryhdria
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8
Q

features

A
iron def anaemia 
loss weight
anorexia
malaena
haematemesis
dysphagia
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9
Q

indiciations for 2wk wait OGD

A

dysphagia (any age)

age ≥55 + weight loss +

  • upper abdo pain/reflux/dyspepsia
  • upper abdo mass
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10
Q

indications for 6wk wait OGD

A

haematemesis (any age)

≥55yrs +

  • Rx resistent dyspepsia
  • upper abdo pain and low Hb
  • raised platelets + other things
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11
Q

Rx - invasive gastirc cancer

A

partial or total gastrectomy + neoadjuvant chemotherapy

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12
Q

Rx - not surgical

A

fluourouracil (chemo) + radiotherapy

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