Fungi Flashcards
Fungi are saprophytic, which means?
Decomposers-secrete digestive enzymes
Fungi are (eukaryotes or prokaryotes?)
Eukaryotes
Disease by fungi are caused by what?
Inflammatory response through direct invasion or destruction of tissues. (some produce toxins)
Cell membranes of fungi are made of what?
Ergosterol
Cell walls of fungi are made of what?
Chitin
3 major categories of Fungi
Yeast-unicellular
Molds-Multicellular
Dimorphic fungi-both mold and yeast
Yeast grow in what?
Buds
Molds grow in what?
Mycelial-vegetative form, a chain
How does mold sexually reproduce?
Spores
How does mold asexually reproduce?
Conidia
3 ways fungi are encountered
Incidental contact
Normal human flora
Contact with infected individual
What is required to eliminate fungal infections?
T cell mediated immunity
What is the primary mechanism for containing fungal infections?
Phagocytosis and killing by neutrophils
Fungal cell walls are unique because they contain what?
Chitin
FUngal membranes are different from animals because they contain
Ergesterol
T/F All molds are dimorphic
False
T/F Yeasts reproduce through the production of spores
False
3 Types of endemic mycoses
Histoplasmosis
Blastomycosis
Coccidioidomycosis
Source of histoplasmosis
Bird and bat poop
Blastomycosis source
Soil mold
Coccidioidomycosis source
Desert soils
In lungs, histoplasma capsulatum transforms into what phase?
Yeast
Histoplasma capsulatum infect what types of cells?
Macrophages
Treatment of histoplasmosis
Self limiting or
Itraconazole for 3-12 months
Blastomycosis is what type of fungus?
Dimorphic- turns to yeast at 37 degrees
Symptoms of blastomycosis
Skin lesions, granulomas
Treatment of blastomycosis
Similar to histoplasmosis
Coccidioidomycosis is found where?
Desert soil
Treatment for coccidiomycosis
Itraconazole
Symptoms of coccidiomycosis
Acute pulmonary infections
Desert rheumatism or valley fever
3 opportunistic fungal pathogens for the test
Candidiasis
Cryptococcosis
Aspergillosis
Candidiasis reproduce by what?
Buds
Dimorphism exception of candidiasis
Mycelial not yeast form found in tissues
All systemic infections of candida are what?
Life threatening
Yeast infections are caused by what?
Candidiasis
Diagnosis of candidiasis
Thrush-scraping of tongue or whatever
Cryptococcosis is most often presented as what?
Meningitis
Treatment for Cryptococcosis
meningitis-Amphotericin B and flucytosine
Pulmonary infections-Fluconazole
Dermatophyte skin infections have 3 etiological genera. What are they?
Microsporum
Trichophyton
Epidermophyton
Tineas is what?
Clinical name for dermatophyte skin infection