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PR - INFECTIONS > FUNGAL INFECTIONS > Flashcards

FUNGAL INFECTIONS Flashcards

1
Q

Aspergillosis

A

Voriconazole

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2
Q

Cryptococcosis

A

Amphotericin B

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3
Q

Oral thrush

A

1st line = miconazole (daktarin) gel
2nd line = nystatin
Extensive/severe = oral fluconazole
Resistant: Itraconazole

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4
Q

Vaginal thrush

A

Caused by candida albicans
1st line = oral azole (fluconazole or itraconazole)
2nd line = intravaginal imidazole pessary or cream (clotrimazole)
Topical antifungal cream can be used to treat superficial symptoms.
o Resistant: Itraconazole

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5
Q

Intravaginal pessary

A

Local irritation may occur - can be mistaken for treatment failure
Can repeat after 7 days if no improvement

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6
Q

Pregnancy

A

DO NOT give oral azoles
Treatment with intravaginal pessaries - longer duration of treatment (7 days) may eb required.
Counsel pt not to use applicator

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7
Q

Skin and nail infections

A
  • Topical therapy → Systemic therapy (itraconazole, terbinafine)
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8
Q

Tinea

A

ringworm

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9
Q

Tinea capitis

A

head

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10
Q

tinea corporis

A

body

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11
Q

tinea cruris

A

groin

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12
Q

tinea pedis

A

feet

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13
Q

tinea ungium/ onchomycosis

A

nails

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14
Q

Treatment for tinea

A
  • Treat with topical antifungal cream or terbinafine
  • Nail region terbinafine or amorolfine nail lacquer
  • Once weekly for up to 1 year
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15
Q

Referral for tinea

A
  • under 18
  • more than 2 nails affected
  • diabetic
  • pregnant / breastfeeding
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16
Q

Fluconazole, Itraconazole, Ketoconazole + Voriconazole

A
  • QT prolongation and hepatotoxicity
  • Less risk in fluconazole, more risk in ketoconazole, voriconazole and itraconazole
17
Q

Itraconazole

A
  • Carbonated drinks improves itraconazole bioavailability
18
Q

Ketoconazole

A
  • Life threatening hepatotoxicity - oral treatment suspended (CHMP advice)
19
Q

Voriconazole

A
  • Phototoxicity occurs uncommonly - avoid sunlight exposure
20
Q

Amphotericin B


A
  • Caution in renal failure

  • Anaphylaxis risk in IV amphotericin B
21
Q

Amphotericin B formulation

A

Maintain same formulation between conventional, liposomal and lipid-complex formulations - Serious harm and fatal overdoses have occurred

22
Q

Amphotericin B anaphylaxis risk

A

Test dose with 30 minutes observation
o Prophylactic antipyretics or hydrocortisone in patients with previous reactions

23
Q

Terbinafine

A

Hepatotoxicity

PR - INFECTIONS (41 decks)

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