CLASSES OF ABX: METRONIDAZOLE Flashcards
1
Q
MOA
A
Prodrug
- Its active form covalently binds to DNA
- disrupts its helical structure
- inhibiting bacterial nucleic acid synthesis
- cell death
2
Q
Activity against
A
Anaerobic bacteria
Protozoa
3
Q
Anaerobic infections
A
Dental infections
Antibiotic associated colitis
H.pylori
Rosacea
BV
4
Q
Protozoal infections
A
Vaginal trichomoniasis
Giardiasis
5
Q
Side effects
A
- Taste disturbance – metallic taste, furred tongue
- N+V (GI disturbances)
- Oral mucositis
- Anorexia
6
Q
Topical use
A
Rosacea
Avoid sunlight/direct UV exposure
7
Q
When to take
A
Take with or after food
8
Q
Monitoring
A
- Clinical and laboratory monitoring advised if treatment exceeds 10 days.
9
Q
With vaginal use
A
- Avoid intravaginal preparations (particularly those that require the use of an applicator) in young girls who are not sexually active, unless there is no alternative (in children);
- not recommended during menstruation
- some systemic absorption may occur with vaginal gel
10
Q
Alcohol and metronidazole
A
- Do NOT drink alcohol
o Avoid alcohol during and 48h after treatment
o Disulfiram like reaction (N+V, flushing)
11
Q
DSLR
A
NV
abdo
flushing
tachy
throbbing headache
syncope
12
Q
Counselling points
A
Take with or just after food
Disulfiram-like reaction with alcohol (i.e. N + V)
Wait 48 hours after stopping reaction before drinking alcohol
13
Q
Pregnancy
A
AVOID
