CLASSES OF ABX: CLINDAMYCIN

Question 1

Drug class

Answer 1

Lincosamide

Question 2

MOA

Answer 2

• Primarily bacteriostatic action against Gram-positive aerobes and a wide range of anaerobic bacteria
• Clindamycin binds to the 50S subunit of the bacterial ribosome to inhibit the early stages of protein synthesis.

Question 3

What bacteria is clindamycin active against?

Answer 3

Gram-positive aerobes and a wide range of anaerobic bacteria

Question 4

Indications

Answer 4

• Staphylococcal joint and bone infections
• Intra-abdominal sepsis
• Cellulitis
• Skin and soft- tissue infections.

Question 5

Side effects of clindamycin

Answer 5

• AAS
• GI SE
• Oesophageal disorders/Taste disturbances
• Jaundice
• Blood disorders

Question 6

What happens if diarrhoea occurs?

Answer 6

• AAC (C.diff)
• May be fatal
• If severe, prolonged, bloody diarrhoea discontinue treatment

Question 7

Symptoms of antibiotic-associated colitis

Answer 7

prolonged or bloody diarrhoea develops

Question 8

Who is Antibiotic-associated colitis more common in?

Answer 8

middle-aged and elderly women, especially after an operation.

Question 9

Contraindication and cautions

Answer 9

existing diarrhoea.

Question 10

Monitoring

Answer 10

Monitor liver and renal function if treatment exceeds 10 days and in infants.