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RES Biweekly 2 > Fouty/Sos- Sarcoidosis > Flashcards

Fouty/Sos- Sarcoidosis Flashcards

1
Q

Multi-system granulomatous disease of unknown cause

A

sarcoidosis

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2
Q
A

non-necrotizing/caseating granuloma

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3
Q

what is a non-caseating granuloma made out of

A

center: sometimes multinucleated giant cell
core: epitheliod histiocytes (macrophages)
surrounded by lymphocytes

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4
Q

goal of _____: confine some pathogen and protect the lung and control inflammation; something could not be completely destroyed so is imprisoned

A

granuloma

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5
Q

lymphocytes that surround granuloma made of what cell mainly

A

CD4 T cell

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6
Q

people with HIV and advanced CD4 depletion don’t make effective what

A

granulomas

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7
Q
A

granuloma

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8
Q

main parts of body that sarcoidosis affects

A

lungs
skin
lymph nodes
eyes

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9
Q

what would you find if you biopsied and confirmed sarcoidosis

A

non-caseating granulomas

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10
Q
A

granulomas in retina

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11
Q

sarcoidosis involves______interstitium

A

peribronchovascular (supports airways and pulm. arteries)

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12
Q
A

granulomas in bronchovascular bundle

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13
Q
A

granulomas in bronchovascular bundle

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14
Q
A

granulomas in bronchovascular bundle

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15
Q
A

station 2R and 10 lymph nodes enlarged (sarcoidosis)

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16
Q

stage?

A

stage 1 sarcoidosis

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17
Q

stage?

A

stage 2 sarcoidosis

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18
Q
A

2R lymph node enlarged

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19
Q

anything that causes lymph nodes to enlarge can _____ structures they are next to

A

compress

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20
Q
A

hilar adenopathy

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21
Q
A

hilar and mediastinal lymph node enlargement

22
Q

28 yr old Scandinavian female w/ hilar adenopathy on CXR

A

sarcoidosis

23
Q

25 yr old AA with hilar adenopathy

A

sarcoidosis

24
Q

bilateral hilar adenopathy on CXR
erythema nodosum
arthralgias
scandinavian
class II HLA antigens

A

Lofgren’s syndrome (sarcoidosis)

25
Q

erythema nodosum + hilar adenopathy

A

sarcoidosis

26
Q
A

erythema nodosum (immunulogic rxn in skin)

27
Q

uveitis
parotiditis
facial nerve palsy
fever

A

Heerfordt’s syndrome (sarcoidosis)

28
Q

what 2 things to think if there is hilar adenopathy

A

sarcoidosis or lymphoma

29
Q

sarcoidosis vs tuberculosis

A

non-caseating granuloma (sarcoid)/ caseating (TB)
acid fast bacilli—-TB

30
Q

necrotizing granuloma think

A

TB

31
Q

diagnosis of exclusion

A

sarcoidosis

32
Q

3 tests for sarcoid patient

A

PFTs
Opthalmic exam
24 hour urine calcium excretion

33
Q

vitamin D producing disease which increases calcium resorption and excess is excreted

A

sarcoidosis

34
Q

Usually restrictive
DLCO usually reduced
(but no classic PFTs for this)

A

sarcoidosis

35
Q

death from sarcoidosis

A

lung disease
cardiac disease

36
Q

lung
skin
eyes
AA’s or scandinavians

A

sarcoidosis pattern

37
Q

African-American aged 30 to 50
Hilar/Mediastinal Adenopathy
Commonly asymptomatic

A

sarcoidosis

38
Q

No ______ needed if classic presentation

A

biopsy

39
Q

problem with granuloma inflammation

A

it doesnt go away

40
Q

Systemic disorder affecting lungs, eyes and skin (and lymph nodes)

A

sarcoidosis

41
Q

Causative agents unknown
(suspected bacteria, fungi, dust and metals)

A

sarcoidosis

42
Q
A

conjunctivitis and papilledema (sarcoidosis)

43
Q

if you see non-caseating granulomas in skin biopsy and a pattern that fits clinical description, think what

A

sarcoidosis

44
Q

pathophys of sarcoidosis

A

Characterized by non-necrotizing granulomas (A granuloma is a mass of cells that wall off foreign antigen)

45
Q

Long standing chronic inflammation gone crazy; poorly formed granulomas; present in different organ systems

A

sarcoidosis

46
Q

enlarged hilar lymph nodes
next step

A

biopsy lymph nodes and find granulomas

47
Q
A

non-caseating granuloma

48
Q
A

caseating granuloma

49
Q
A

granulomas

50
Q
A

3 granulomas I can see in

RES Biweekly 2 (14 decks)

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