Fouty/Sos- Sarcoidosis Flashcards by Madeline Wing

Multi-system granulomatous disease of unknown cause

sarcoidosis

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non-necrotizing/caseating granuloma

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what is a non-caseating granuloma made out of

center: sometimes multinucleated giant cell
core: epitheliod histiocytes (macrophages)
surrounded by lymphocytes

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goal of _____: confine some pathogen and protect the lung and control inflammation; something could not be completely destroyed so is imprisoned

granuloma

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lymphocytes that surround granuloma made of what cell mainly

CD4 T cell

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people with HIV and advanced CD4 depletion don’t make effective what

granulomas

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granuloma

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main parts of body that sarcoidosis affects

lungs
skin
lymph nodes
eyes

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what would you find if you biopsied and confirmed sarcoidosis

non-caseating granulomas

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granulomas in retina

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sarcoidosis involves______interstitium

peribronchovascular (supports airways and pulm. arteries)

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granulomas in bronchovascular bundle

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granulomas in bronchovascular bundle

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granulomas in bronchovascular bundle

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station 2R and 10 lymph nodes enlarged (sarcoidosis)

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stage?

stage 1 sarcoidosis

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stage?

stage 2 sarcoidosis

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2R lymph node enlarged

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anything that causes lymph nodes to enlarge can _____ structures they are next to

compress

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hilar adenopathy

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hilar and mediastinal lymph node enlargement

28 yr old Scandinavian female w/ hilar adenopathy on CXR

sarcoidosis

25 yr old AA with hilar adenopathy

sarcoidosis

bilateral hilar adenopathy on CXR
erythema nodosum
arthralgias
scandinavian
class II HLA antigens

Lofgren’s syndrome (sarcoidosis)

erythema nodosum + hilar adenopathy

sarcoidosis

erythema nodosum (immunulogic rxn in skin)

uveitis parotiditis facial nerve palsy fever

Heerfordt's syndrome (sarcoidosis)

what 2 things to think if there is hilar adenopathy

sarcoidosis or lymphoma

sarcoidosis vs tuberculosis

non-caseating granuloma (sarcoid)/ caseating (TB) acid fast bacilli----TB

necrotizing granuloma think

diagnosis of exclusion

sarcoidosis

3 tests for sarcoid patient

PFTs Opthalmic exam 24 hour urine calcium excretion

vitamin D producing disease which increases calcium resorption and excess is excreted

sarcoidosis

Usually restrictive DLCO usually reduced (but no classic PFTs for this)

sarcoidosis

death from sarcoidosis

lung disease cardiac disease

lung skin eyes AA's or scandinavians

sarcoidosis pattern

African-American aged 30 to 50 Hilar/Mediastinal Adenopathy Commonly asymptomatic

sarcoidosis

No ______ needed if classic presentation

biopsy

problem with granuloma inflammation

it doesnt go away

Systemic disorder affecting lungs, eyes and skin (and lymph nodes)

sarcoidosis

Causative agents unknown (suspected bacteria, fungi, dust and metals)

sarcoidosis

conjunctivitis and papilledema (sarcoidosis)

if you see non-caseating granulomas in skin biopsy and a pattern that fits clinical description, think what

sarcoidosis

pathophys of sarcoidosis

Characterized by non-necrotizing granulomas (A granuloma is a mass of cells that wall off foreign antigen)

Long standing chronic inflammation gone crazy; poorly formed granulomas; present in different organ systems

sarcoidosis

enlarged hilar lymph nodes next step

biopsy lymph nodes and find granulomas

non-caseating granuloma

caseating granuloma

granulomas

3 granulomas I can see in