Fossum Table 5.1 Flashcards
What are the 4 types of antiseptics?
- Iodine/iodophors (PVI)
- Alcohol (IPA)
- CHG
- Alcohol-based solutions
What is the mode of action of iodine/iodophors (PVI)?
Penetration of the cell wall and oxidation and replacement of intracellular molecules with free iodine.
What are iodophors?
Solutions of iodine with a surfactant or stabilizing agent that liberates free iodine.
What is the activity of iodine/iodophors (PVI)?
Wide range of bacteria, tubercle bacilli, and some spores (e.g. Clostridia).
What greatly reduces the activity of iodine/iodophors (PVI)?
Presence of organic material (pus and exudates).
What is the mode of action of alcohol (IPA)?
Rapidly denatures bacterial cell wall proteins and biomolecules (DNA, RNA, lipids).
What is the activity of alcohol (IPA)?
Wide range of bacteria, tubercle bacilli, and many fungi and viruses.
What is the mode of action of CHG?
Disrupts cell membrane and precipates cellular contents.
What is the activity of CHG?
Wide range of bacteria
CHG is more effective against _____ bacteria than _____ bacteria.
gram-positive, gram-negative
What does CHG have minimal activity against?
Tubercle bacteria, Mycobacterium spp., and fungi
What is the mode of action os alcohol-based solutions?
Combo of the MOA of the other 3 types of antiseptics
What is the activity of alcohol-based solutions?
Broad spectrum due to combo of several antiseptics with different MOA.
What does CHG stand for?
chlorhexidine gluconate
What does IPA stand for?
isopropyl alcohol
