For Exam #2 Flashcards
The nervous system can structurally be divided into what two categories?
central nervous system (CNS)
peripheral nervous system (PNS)
What structures are in the CNS?
brain and spinal cord (protected by cranium, vertebral canal)
What structures are in the PNS?
cranial nerves and spinal nerves
The nervous system can be functionally divided into what three categories?
sensory, motor, and integration components
What does the sensory component do?
carries sensation to the brain and spinal cord
What does the motor component do?
delivers impulses to muscles and glands
What does the integration center do?
helps to process sensory input and organize motor output
The sensory system is divided into what two systems?
somatic sensory system and visceral sensory system
What does the somatic sensory part of the nervous system do?
carries sensory information we are generally aware of (such as touch from the skin, vision, hearing, smells, and taste)
What is the visceral sensory part of the nervous system do?
carries sensory information we are generally not aware of (such as amount of oxygen and carbon dioxide in the blood or the make-up of food traveling through the digestive tract)
What does the somatic motor part of the nervous system do?
delivers impulses to skeletal muscles, which we generally control voluntarily
What does the visceral motor (autonomic) part of the nervous system do?
delivers impulses to cardiac muscle, smooth muscle and glands, which are generally controlled automatically (without conscious effort)
Characteristics of a Neuron
- high metabolic activity requiring constant supply of glucose and oxygen
- not capable of cell division (nonmitotic)
- cell body is control center of cell and contains the nucleus
- prominent nucleolus indicative of high metabolic activity
- large number of mitochondria to produce ATP for energy
What do dendrites do?
carry impulses to cell bodoy
What does the axonal process do?
carries impulse away from cell body
- often myelinated
What is the axon hillock?
where the cell body tapers down to the axon
What are telodendria?
branches at the terminal end of axons
What are on the ends of telodendria?
synaptic knobs that can release neurotransmitters
What are the cells of the nervous system?
neurons
interneurons
glial cells
What are the three structural classification of neurons?
bipolar neurons
unipolar (pseudounipolar) neurons
multipolar neurons
Bipolar Neurons
- have one dendritic process and one axonal process
- found in retina of eye (vision) and olfactory epithelium of nose (smell)
Unipolar (Pseudounipolar) Neurons
- dendritic and axonal processes fuse to form a single process, but still functionally separate
- carry sensation from the SKIN
- dendritic branches have specialized sensory receptors for touch, pressure, vibration, pain, and temperature
- cell bodies located outside the CNS
- axonal processes enter spinal cord posteriorly
- collection of cell bodies is called a ganglion
Multipolar Neurons
- have a single axon and multiple dendritic processes
- function as motor neurons and interneurons
- can have sparsely-branched or extensively-branched dendritic arbors
What are the functional classifications of neurons?
sensory neurons
motor neurons
interneurons
Sensory Neurons (AKA afferents)
- carry sensation from the skin to the CNS
- are unipolar
- their cell bodies form ganglia
- axonal processes enter the brain or spinal cord
Motor Neurons (AKA efferents)
- deliver impulses (motor commands) to muscles and glands
- multipolar
- cell bodies are in the spinal cord (in ventral horns) and their axons project out to their targets
What is a ganglion?
collection of cell bodies in the PNS
Interneurons (AKA association neurons)
- multipolar and entirely located within the CNS, specifically within the gray matter of the spinal cord
- receive information from sensory neurons and “decide” what to do with it
- may decide to send information up to the cerebral cortex for awareness
- may decide to send the information to motor neurons in anterior horn for motor response
Glial Cells (AKA neuroglia = nerve glue)
- provide a wide range of supportive functions in the CNS and PNS (protect, nourihs, and provide supporting networks for neurons)
- smaller and more numerous than neurons
- do not conduct impulses
- capable of cell division
What are the four types of glial cells in the CNS?
astrocytes
ependymal cells
microglia
oligodendrocytes
What are the two types of glial cells in the PNS?
satellite cells
neurolemmocytes (Schwann cells)
Astrocytes
- have processes which extend to neurons and capillaries
- help regulate what leaves the capillaries and enters the interstitial space (around the neurons)
- part of the blood brain barrier
- fill in space left by dead cells to maintain structural integrity of CNS
- release small “bursts” of calcium to influence neuronal activity
What is the blood-brain barrier?
a modification of capillaries in the brain which protects the nervous tissue from substances that could adversely affect brain function
- consists of specializations of the capillaries (tight junctions and continuous basement membrane) and the perivascular feet of astrocytes)
What kinds of substances can diffuse across the blood-brain barrier?
lipid-soluble compounds such as alcohol, nicotine, and some anesthetics
Ependymal Cells
- have somewhat cuboidal shape with cilia
- join capillaries to form choroid plexus (found in ventricles of brain, produces cerebrospinal fluid [CSF])
- the cilia of the ependymal cells help circulate CSF
Function of cerebrospinal fluid (CSF)
provide nourishment and protection for CNS
Microglia
- especially small
- wander through the CNS and clean up debris from dead cells via phagocytosis
Oligodendrocytes
- have multiple projections that project out to nearby axons
- the projections wrap around regions of axons to produce myelin
- myelin increases conduction velocity in neurons
What are gaps in the myelin sheath called?
nodes of Ranvier
- responsible for saltatory conduction (jumping) in axons
What is the only place where reversal of polarity occurs in an axon?
in the nodes of Ranvier
Why is it desirable to insulate some neurons?
insulating them increases the speed that the impulse can travel
Satellite Cells
- located around unipolar cell bodies of dorsal root ganglia
- help deliver nutrients and remove waste products
Neurolemmocytes (Schwann Cells)
- myelinate neuronal processes (motor and sensory) in peripheral nerves
- each neurolemmocyte attaches to a segment of a neuronal process and wraps its cell membrane around it to form myelin
- assists with nerve regeneration
Endoneurium
the connective tissue around a single axon
Perineurium
the connective tissue around a bundle of axons (fascicle)
Epineurium
the connective tissue around a peripheral nerve
When a peripheral nerve is cut, what ends of the nerve processes (both sensory and motor) degenerate?
the distal ends
During nerve regeneration, what happens to the ends of the processes still attached to the cell bodies?
they seal off and swell
During nerve regeneration, the neurolemmocytes for a regenerate rube and secrete what?
nerve growth factor (NGF)
What does nerve growth factor (NGF) do in nerve regeneration?
signals the end of the neuronal process to sprout and extend down the regeneration tube to the muscle or skin
Why is regeneration less likely to occur in the CNS?
- neurons are more tightly packed
- no neurolemmocytes (and therefore no NGF)
- astrocytes tend to fill in the space left by the degenerated neuronal processes
What three things does successful regeneration depend on?
- amount of damage
- secretion of nerve growth factor (NGF) by neurolemmocytes
- distance between damaged axons and target organ
An impulse travels down an axon and its terminal branches as a result of _____ entering the cells and reversing the relative polarity across the cell membrane
sodium
Spinal Cord
- link between the brain and the rest of the body
- protected by vertebral canal and meninges (pia mater, arachnoid mater, and dura mater)
What is located in the subarachnoid space?
cerebrospinal fluid (CSF)
What defines the segments of the spinal cord?
attachment of a pair of spinal nerves
How many cervical segments in the spinal cord?
8
How many thoracic segments in the spinal cord?
12
How many lumbar segments in the spinal cord?
5
How many sacral segments in the spinal cord?
5
Which spinal cord regions are enlarged for the extremities?
cervical and lumbar regions
Where does the spinal cord end?
at the L1 level of the vertebral column as conus medullaris
Cauda Equina
Meaning horse tail; a collection of nerve roots at the end of the spinal cord
Gray matter is on the ____ of the spinal cord while white matter is on the _____.
inside ; outside
Central processes of sensory neurons enter the…
posterior (dorsal) horns
The posterior root ganglia are made of…
sensory (unipolar) neuron cell bodies
Where are the cell bodies of interneurons located?
posterior (dorsal) horns
The cell bodies of motor neurons are located in the…
anterior (ventral) horns
The axons of motor neurons leave the spinal cord ____, forming ________.
anteriorly ; anterior roots
Anterior and posterior roots join to form what?
a spinal nerve
Spinal nerves divide into….
posterior and anterior rami
Posterior Rami
Deliver motor fibers to skeletal muscles along vertebral column and carry sensation from overlying skin
Anterior Rami
Deliver motor fibers to skeletal muscles of the body wall and extremities, as well as carry sensation from skin of body wall and extremities
Nerve Plexuses
joining of anterior rami to form nerves comprised of more than one level of the spinal cord
Where are nerve plexuses found and why?
The upper and lower extremities, because they perform complex, graded functions
What are the two largest nerve plexuses?
brachial plexus and lumbosacral plexus
Brachial Plexus
delivers motor to, and sensory from, the upper extremity
Lumbosacral Plexus
delivers motor to, and sensory from, the lower extremity
What forms the brachial plexus?
anterior rami of spinal nerves C5-T1
Where is the brachial plexus?
it extendsf rom the lower neck, between the clavicle and 1st rib, and then into the axilla.
What does the brachial plexus do?
Innervates the skeletal muscles of the upper extremity and carries sensation from the skin of the upper extremity
Anterior rami of C5 and C6 join to form…
the superior trunk
Anterior rami of C8 and T1 join to form…
the inferior trunk
Anterior ramus of C7 forms…
the middle trunk
The posterior branches of all 3 brachial plexus trunks form…
the posterior cord
The anterior branches of the superior and middle brachial plexus trunks form…
the lateral cord
The anterior branch of the brachial plexus’s inferior trunk forms…
the medial cord
The posterior cord gives rise to what nerves?
radial and axillary
The lateral cord gives rise to…
the musculocutaneous nerve and part of the median nerve
The medial cord gives rise to the…
ulnar nerve and part of the medial nerve.
Axillary Nerve
- spinal cord levels C5 and C6
- motor signals to deltoid and teres minor
Main Function of Axillary Nerve
abduction and external rotation of the arm
responsible for sensation from skin of lateral shoulder
Musculoskeletal Nerve
- spinal cord levels C5-C7
- motor signal to biceps brachii, corachobracialis, and brachialis
Main Function of Musculoskeletal
flexion at the elbow
sensation of skin of lateral forearm
Radial Nerve
- spinal cord levels C5-T1
- motor signals to triceps, anconeous, brachioradialis, extensory carpi ulnaris, supinator, abductor pollicis longus, extensor pollicis brevis, extensory pollicis longus, and extensory indicis