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FIP Flashcards

1
Q

What marker is used to identify ALL lymphocytes?

A

CD45

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2
Q

What lymphoma is identified by CD45?

A

All lymphomas

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3
Q

What IHC stain is used to identify carcinomas in general?

A

Cytokeratin

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4
Q

What tumour is identified by the IHC stain, cytokeratin?

A

Carcinomas

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5
Q

What marker is used to identify sarcomas?

A

Vimentin

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6
Q

What marker is used to identify prostatic carcinomas?

A

PSA (prostate specific antigen)

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7
Q

What marker is used to identify melanomas (3)?

A

MelA, S100, HMB45

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8
Q

What marker is used to identify choriocarcinomas?

A

HCG

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9
Q

What marker is used to identify yolk sac or hepatocellular carcinomas?

A

Alpha-fetoprotein

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10
Q

What marker is used to identify cancer in the colon, stomach, pancreas and breast?

A

Carcinoembryogenic antigen (CEA)

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11
Q

What tumour is identified by the marker, Vimentin?

A

Sarcomas

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12
Q

What tumour is identified by the marker, PSA?

A

Prostatic carcinoma

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13
Q

What tumour is identified by the marker, MelA, S100, HMB45?

A

Melanomas

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14
Q

What tumour is identified by the marker HCG?

A

Choriocarcinomas

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15
Q

What tumours are identified by the marker Alpha-fetoprotein?

A

Yolk sac or hepatocellular carcinomas

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16
Q

What tumours are identified by the marker Carcinoembryogenic antigen (CEA)?

A

Colon, stomach, pancreas and breast cancer

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17
Q

What markers are used to identify Reed-Sternberg or hodgkin’s cells (hodgkin’s lymphoma)?

A

CD30 and CD15

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18
Q

What marker is used to identify T cell lymphomas?

A

CD3

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19
Q

What marker is used to identify mantle cell lymphoma t(11:14)?

A

Cyclin D1

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20
Q

What markers are used to identify B cell lymphomas?

A

CD20 and CD79a

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21
Q

What markers are used to identify follicular lymphomas t(14:18)?

A

Bcl-2 and CD10

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22
Q

What markers are used to identify small B cell lymphocytic lymphomas?

A

CD5 and CD23

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23
Q

What lymphoma is identified by CD30 and CD15?

A

Reed-Sternberg or hodgkin’s cells (hodgkin’s lymphoma)

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24
Q

What lymphoma is identified by CD3?

A

T cell lymphomas

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25
Q

What lymphoma is identified by Cyclin D1?

A

Mantle cell lymphoma t(11:14)

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26
Q

What lymphoma is identified by CD20 and CD79a?

A

B cell lymphomas

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27
Q

What lymphoma is identified by Bcl-2 and CD10?

A

Follicular lymphomas (commonest lowest grade B cell lymphoma) t(14:18)

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28
Q

What lymphoma is identified by CD5 and CD23?

A

Small B cell lymphocytic lymphomas

29
Q

What lymphoma is identified by c-myc?

A

Burkitt’s Lymphoma t(8:14)

30
Q

What lymphoma is identified by ALK+ or ALCL?

A

Large B and T cell lymphoma

31
Q

What lymphoma is identified by Bcl-6?

A

Diffuse Large B-cell Lymphoma

32
Q

What oncogene is used to identify Large B and T cell lymphoma?

A

ALK+ or ALCL

33
Q

What oncogene is used to identify Burkitt’s Lymphoma t(8:14)?

34
Q

What oncogene is used to identify Diffuse Large B-cell Lymphoma?

35
Q

What marker is used for immature T cells?

36
Q

What is TDT used to identify?

A

Immature T cells

37
Q

What marker is used to indicate uncontrolled cell cycling and development of lymphomas?

38
Q

What is P53 used to identify?

A

uncontrolled cell cycling and development of lymphomas

39
Q

What marker is used for thyroid tumours?

A

Thyroglobulin

40
Q

What tumour is identified by thyroglobulin?

A

thyroid tumours

41
Q

What marker is used to identify ovarian cancer?

42
Q

What tumour is CA-125 used to identify?

A

Ovarian cancer

43
Q

What marker is common for CD4 and CD8 T cells?

44
Q

What marker is used to identify double positive immature T cells?

45
Q

What is reticulin used to identify?

A

Stromal reactions in Bone marrow metastasis

46
Q

What is LDH used to identify?

A

Lymphoproliferative disorder

47
Q

Example of where a increase in LDH would be observed?

A
  • high grade non-hodgkin’s lymphoma
48
Q

What is identified by estrogen and Her2 receptors?

A

Breast cancer

49
Q

What markers are used to identify adenocarcinomas?

A

AE1-3
Cytokeratin 7
Napsin A

50
Q

What markers are used to identify squamous cell carcinomas?

A

cytokeratin 7
CK5/6
P63
AE1-3

51
Q

what marker is used for neuroendocrine tumours?

A

Synaptophysin
Chromogranin
CD56

52
Q

What marker is used for colorectal tumour?

A

cytokeratin 20

CdX2

53
Q

marker for Stromal reactions in Bone marrow metastasis

54
Q

marker for Breast cancer

A

estrogen receptors

Her2

55
Q

AE1-3
Cytokeratin 7
Napsin A
are used to identify what carcinoma?

A

adenocarcinomas

56
Q 
cytokeratin 7
CK5/6
P63
AE1-3
are used to identify what carcinoma?
A

squamous cell carcinomas

57
Q

Synaptophysin
Chromogranin
CD56
are used to identify what carcinoma?

A

neuroendocrine tumours
e.g. small cell lung carcinoma
large cell carcinoid tumour

58
Q

cytokeratin 20
CdX2
are used to identify what tumour?

A

colorectal tumour

59
Q

what is c-kit used to identify?

A

gastrointestinal stromal tumours

60
Q

what marker is used to identify gastrointestinal stromal tumours?

61
Q

what is c-ret (MEN2a/MEN2b) used to identify?

A

Thyroid cancer

62
Q

what marker is used to identify Thyroid cancer?

A

c-ret (MEN2a/MEN2b)

63
Q

what is Bcr-abl (philadelphia chromosome) t(9:22) used to identify?

A

CML
ALL
Myelofibrosis

64
Q

what marker is used to identify CML?

A

Bcr-abl (philadelphia chromosome) t(9:22)

65
Q

what marker is used to identify ALL?

A

Bcr-abl (philadelphia chromosome) t(9:22)

66
Q

what marker is used to identify Myelofibrosis?

A

Bcr-abl (philadelphia chromosome) t(9:22)

67
Q

what marker is used to identify small cell B cell lymphoma?

68
Q

what is C5 and CD23 used to identify?

A

small cell B cell lymphoma

Finals (17 decks)

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