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FIP Flashcards

1
Q

What marker is used to identify ALL lymphocytes?

A

CD45

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2
Q

What lymphoma is identified by CD45?

A

All lymphomas

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3
Q

What IHC stain is used to identify carcinomas in general?

A

Cytokeratin

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4
Q

What tumour is identified by the IHC stain, cytokeratin?

A

Carcinomas

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5
Q

What marker is used to identify sarcomas?

A

Vimentin

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6
Q

What marker is used to identify prostatic carcinomas?

A

PSA (prostate specific antigen)

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7
Q

What marker is used to identify melanomas (3)?

A

MelA, S100, HMB45

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8
Q

What marker is used to identify choriocarcinomas?

A

HCG

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9
Q

What marker is used to identify yolk sac or hepatocellular carcinomas?

A

Alpha-fetoprotein

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10
Q

What marker is used to identify cancer in the colon, stomach, pancreas and breast?

A

Carcinoembryogenic antigen (CEA)

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11
Q

What tumour is identified by the marker, Vimentin?

A

Sarcomas

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12
Q

What tumour is identified by the marker, PSA?

A

Prostatic carcinoma

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13
Q

What tumour is identified by the marker, MelA, S100, HMB45?

A

Melanomas

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14
Q

What tumour is identified by the marker HCG?

A

Choriocarcinomas

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15
Q

What tumours are identified by the marker Alpha-fetoprotein?

A

Yolk sac or hepatocellular carcinomas

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16
Q

What tumours are identified by the marker Carcinoembryogenic antigen (CEA)?

A

Colon, stomach, pancreas and breast cancer

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17
Q

What markers are used to identify Reed-Sternberg or hodgkin’s cells (hodgkin’s lymphoma)?

A

CD30 and CD15

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18
Q

What marker is used to identify T cell lymphomas?

A

CD3

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19
Q

What marker is used to identify mantle cell lymphoma t(11:14)?

A

Cyclin D1

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20
Q

What markers are used to identify B cell lymphomas?

A

CD20 and CD79a

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21
Q

What markers are used to identify follicular lymphomas t(14:18)?

A

Bcl-2 and CD10

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22
Q

What markers are used to identify small B cell lymphocytic lymphomas?

A

CD5 and CD23

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23
Q

What lymphoma is identified by CD30 and CD15?

A

Reed-Sternberg or hodgkin’s cells (hodgkin’s lymphoma)

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24
Q

What lymphoma is identified by CD3?

A

T cell lymphomas

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25
What lymphoma is identified by Cyclin D1?
Mantle cell lymphoma t(11:14)
26
What lymphoma is identified by CD20 and CD79a?
B cell lymphomas
27
What lymphoma is identified by Bcl-2 and CD10?
Follicular lymphomas (commonest lowest grade B cell lymphoma) t(14:18)
28
What lymphoma is identified by CD5 and CD23?
Small B cell lymphocytic lymphomas
29
What lymphoma is identified by c-myc?
Burkitt's Lymphoma t(8:14)
30
What lymphoma is identified by ALK+ or ALCL?
Large B and T cell lymphoma
31
What lymphoma is identified by Bcl-6?
Diffuse Large B-cell Lymphoma
32
What oncogene is used to identify Large B and T cell lymphoma?
ALK+ or ALCL
33
What oncogene is used to identify Burkitt's Lymphoma t(8:14)?
C-myc
34
What oncogene is used to identify Diffuse Large B-cell Lymphoma?
Bcl-6
35
What marker is used for immature T cells?
TDT
36
What is TDT used to identify?
Immature T cells
37
What marker is used to indicate uncontrolled cell cycling and development of lymphomas?
P53
38
What is P53 used to identify?
uncontrolled cell cycling and development of lymphomas
39
What marker is used for thyroid tumours?
Thyroglobulin
40
What tumour is identified by thyroglobulin?
thyroid tumours
41
What marker is used to identify ovarian cancer?
CA-125
42
What tumour is CA-125 used to identify?
Ovarian cancer
43
What marker is common for CD4 and CD8 T cells?
CD3
44
What marker is used to identify double positive immature T cells?
CD3
45
What is reticulin used to identify?
Stromal reactions in Bone marrow metastasis
46
What is LDH used to identify?
Lymphoproliferative disorder
47
Example of where a increase in LDH would be observed?
- high grade non-hodgkin's lymphoma
48
What is identified by estrogen and Her2 receptors?
Breast cancer
49
What markers are used to identify adenocarcinomas?
AE1-3 Cytokeratin 7 Napsin A
50
What markers are used to identify squamous cell carcinomas?
cytokeratin 7 CK5/6 P63 AE1-3
51
what marker is used for neuroendocrine tumours?
Synaptophysin Chromogranin CD56
52
What marker is used for colorectal tumour?
cytokeratin 20 | CdX2
53
marker for Stromal reactions in Bone marrow metastasis
reticulin
54
marker for Breast cancer
estrogen receptors | Her2
55
AE1-3 Cytokeratin 7 Napsin A are used to identify what carcinoma?
adenocarcinomas
56
``` cytokeratin 7 CK5/6 P63 AE1-3 are used to identify what carcinoma? ```
squamous cell carcinomas
57
Synaptophysin Chromogranin CD56 are used to identify what carcinoma?
neuroendocrine tumours e.g. small cell lung carcinoma large cell carcinoid tumour
58
cytokeratin 20 CdX2 are used to identify what tumour?
colorectal tumour
59
what is c-kit used to identify?
gastrointestinal stromal tumours
60
what marker is used to identify gastrointestinal stromal tumours?
c-kit
61
what is c-ret (MEN2a/MEN2b) used to identify?
Thyroid cancer
62
what marker is used to identify Thyroid cancer?
c-ret (MEN2a/MEN2b)
63
what is Bcr-abl (philadelphia chromosome) t(9:22) used to identify?
CML ALL Myelofibrosis
64
what marker is used to identify CML?
Bcr-abl (philadelphia chromosome) t(9:22)
65
what marker is used to identify ALL?
Bcr-abl (philadelphia chromosome) t(9:22)
66
what marker is used to identify Myelofibrosis?
Bcr-abl (philadelphia chromosome) t(9:22)
67
what marker is used to identify small cell B cell lymphoma?
C5 | CD23
68
what is C5 and CD23 used to identify?
small cell B cell lymphoma

Finals (17 decks)

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