Final Review Flashcards
Perfusion is a function of:
BP, HR, CO, SV, SVR
___ is a state of collapse & failure of the cardiovascular system
Shock
The time just before or just after cardiac arrest
Peri-arrest period
Conditions that preceded the onset of a disease
Premorbid conditions
Premorbid conditions that affect healthy adults
Drug toxicity, electrolyte imbalance, pulmonary embolus
Chosen from a differential list used to base a treatment plan
Working diagnosis
M in “M-T SHIP”
Medication issues, metabolic causes
T in “M-T SHIP”
Trauma, tumor, toxins
S in “M-T SHIP”
Seizure, stroke
H in “M-T SHIP”
Hypoxia, hyper/hypothermia, hyper/Hypoglycemia, hypertensive crisis, hypovolemia, hyper/hypokalemia
I in “M-T SHIP”
Infection & uremia
P in “M-T SHIP”
Psychiatric/behavioral disorders
Tendency to gather & rely on information that confirms existing views
Confirmation bias
Allowing initial viewpoints to distort your estimates
Anchoring bias
Operational practice designed to enhance communication & teamwork
Crew resource management
Concept describing the relationship between myocardial contractility & cardiac output
Frank-Starting mechanism
Resistance to blood flow within all vessels except pulmonary vessels
SVR
The blood pressure required to sustain organ perfusion
Mean arterial pressure
MAP is roughly ___ in the average person
60
MAP formula
MAP = DBP + 1/3 (SBP-DBP [pulse pressure])
Pulse pressure is found by this formula
SBP - DBP
Control of the cardiovascular system is a function of the:
Autonomic nervous system
A decrease in SBP below 80 mmHg stimulates the ___ to increase arterial pressure through vasoconstriction
Vasomotor center of the medulla oblongata
Time that a tissue can be deprived of oxygen before it starts to die
Warm ischemic time
Major cause of death following septic, traumatic, and burn injuries
MODS
Multi-organ dysfunction syndrome
Group of plasma proteins that functions to eliminate invading bacteria
Complement system
Pediatric patients can compensate for blood loss up to as much as:
30%-35%
Fluid challenge volume for an adult with moderate or severe hypotension
250 mL followed by reevaluation of BP, up to 4 doses
Shock classification that divides types of shock into central or peripheral shock
Weil-Shubin classification
Beck triad of cardiac tamponade
JVD
Narrowing pulse pressures
Muffled heart tones
___ occurs when the heart is unable to sufficiently circulate blood to sustain peripheral perfusion
Cardiogenic shock
2 main causes of obstructive shock:
Cardiac tamponade & tension pneumothorax
If the septic patient is normotensive after initial fluid therapy, administer ___ to maintain BP & renal precision
Dopamine
If the septic patient is hypotensive & vasodilators in “watml shock, administer:
Norepinephrine
If the septic patient is hypotensive in “cold” shock, administer:
Epinephrine
Fluid bolus dose for septic patients:
30 mL/kg
Neurogenic shock usually results from:
Spinal cord injury
A characteristic sign of neurogenic shock is:
Absence of seating below the level of the cord injury
Disruption or loss of normal GI motility
Ileus
___ occurs when there is widespread dilation of resistance or capacitance vessels (arterioles & venules)
Distributive shock
___ medications initiate or alter cellular activity by binding to receptor sites and promoting a response
Agonist
___ medications prevent chemicals from reaching receptors and initiating or altering particular cellular activity
Antagonist
Binding of ___ receptors causes vasoconstriction, while ___ receptor binding causes vasodilation
Alpha; beta
Concentration of a medication required to initiate cellular response
Potency
Ability of a medication to initiate or alter cell activity therapeutically
Efficacy
___ antagonists temporarily bind with receptor sites, displacing other chemicals
Competitive
___ antagonists permanently bind with receptors and block activation by agonist chemicals
Noncompetitive
___ bind to receptors but do not initiate as much cellular activity or change as others
Partial agonists
Careful titration of medication doses may be required in:
Pediatric or geriatric patients
Medication metabolism in the liver is affected by the:
Cytochrome P-450 system
Patients at extremes of age are prone to ___ medication reactions
Paradoxical
Ideal body weight formula for men:
50+(2.3 X height in inches over 60”)
Ideal body weight formula for women
45.5+(2.3 X height in inches over 60”)
Risks associated with meds in pregnancy class __ outweigh any potential benefits to the mother
X
Possibility of fetal harm in 1st trimester from meds in pregnancy class __ are remote
A
Meds in pregnancy class __ have not been studied thoroughly enough to determine risks to the fetus in the first trimester
B
Meds in pregnancy class __ should only be given if the potential benefits outweigh the risks to the fetus
C
Meds in pregnancy class __ have known fetal risks, but benefits to the woman may be acceptable if the benefits outweigh the risks
D
Several smaller doses of a med may be capable of producing the same effects of a single larger dose
Cumulative action
Completely unexpected adverse reactions not known to occur with a particular med
Idiosyncratic reactions
Reduction of available receptors for a particular drug resulting in tolerance
Down-regulation
Decreased efficacy of a drug due to frequent usage
Tolerance
Condition in which repeated doses of a medication within a short time frame may cause tolerance/decreased efficacy
Tachypnylaxis
Physical tolerance and psychological dependence on a medication
Habituation
Physical, emotional, or behavioral need for a particular substance
Dependence
Undesirable medication interactions
Interference
Med combination that produces a greater effect than the sum of the individual effects
Synergism
Enhancement of the effects of a medication by another
Potentiation
Two medications binding together creating an inactive substance
Neutralization
Percentage of unaltered medication that reaches systemic circulation
Bioavailability
Insulin restriction, glucagon secretion, and inhibition of norepinephrine release are the agonist effects of what type of receptors?
Alpha 2
Agonist binding of ___ receptors causes vasodilation of mesenteric arteries
Dopaminergic
The ___ of a medication is lower for medications with a higher potency
threshold dose
% Of RBC’s in the intravascular space
hematocrit
A drug’s bioavailability is altered by all administration routes except:
IV
In addition to GI motility, pH, and presence of food/liquid, GI medications are subjected to ___
first pass metabolism
GI medications pass from the GI tract into the ___ and then to the ___
Portal vein; liver
Alteration of a medication via metabolism within the GI tract before it reaches systemic circulation
first-pass effect
___ is the amount of time needed in an average Person to metabolize or eliminate 50% of a substance in plasma
half-life
All Beta agents have a ___ effect on the heart.
stimulant
In the lungs, alpha agents cause:
Minor bronchoconstriction
Parasympathetic blocker that opposes the vagus nerve to speed up the heart after excessive vagal stimulation/firing has caused bradycardia
atropine
Parasympathetic agent used primarily to induce vasoconstriction & increase bp
Norepinephrine
Sympathetic agent used to increase renal perfusion, increase HR & myocardial contractility, and constrict peripheral vessels
dopamine
___ blockers will reduce HR & BP
Calcium-channel
Clopidogrel (plavix) is a ____
platelet inhibitor