FINAL EXAM Flashcards
Dependence on a substance
Addiction
Morbid sadness, most common adult psychiatric, disorder
Depression
Lithium is the treatment of choice
Bipolar disorder
Best treatment is light therapy
Seasonal affective disorder
Emotional state of fear
Anxiety disorder
Symptoms include a persistent re-experiencing of a trauma
Post traumatic stress disorder (PTSD)
Panic attack is a type of ___ disorder
Panic disorder/ anxiety disorder
Abnormal fear and apprehension followed by obsessions
Obsessive compulsive disorder (OCD)
Eating disorder characterized by abnormally low weight with an intense fear of gaining weight
Anorexia nervosa
General symptoms of anemia
fatigue, headache, chest pain, irregular heart beat, cold intolerance, shortness of breath, pallor, dizziness, brittle hair, spoon shaped nails, delayed healing, swollen ankles, sore/beefy red tongue, cracked lips & intermittent calf pain
Iron deficiency anemia
most common especially for women
Idiopathic anemia
bone marrow stops making RBCs
Pernicious anemia
lack of Vit. B12
Folic acid anemia
lack of folic acid, causes spina bifida in neonates (newborns)
Sickle cell anemia
RBC shape changes, live less, and stick together
Aplastic anemia
rate and life threatening, complete marrow failure
g. Nutritional anemia – lack of iron, protein, Vit. B12
Hemolytic anemia
RBCs destroyed faster than they can be replaced
Hemorrhagic anemia
results from massive blood loss
Impaired clotting mechanisms, causing prolonged bleeding
Hemophilia
Impaired bone marrow function in making WBCs
Leukemia
A fungal infection from inhaled spores found in soil, bird & bat droppings
Histoplasmosis
Borrelia Burgdorferi
LYME DISEASE
Borrelia Burgdorferi: a spirochete & a bacteria – injected into body by a tick bite from deer tick
Chancre
-untreated SYPHILIS:
primary stage: primary lesion appears at initial site of infection, called a CHANCRE, which heals in 1-2 months, infection spreads throughout body
Virus hides in the dorsal root ganglion
Herpes virus
Oral lesions
Herpes simplex 1
“Cold sores”, painful blisters
Genital lesions
Herpes simplex 2
Causes genital blister-like sores that are often painful, blisters heal over & crust within 7-10 days
Shingles
-virus causes chickenpox, after chicken pox, virus lays dormant in peripheral nervous system in dorsal root ganglia of spinal nerve – stays latent until activated by stress, usually later in life
-causes painful rash along sensory nerves dermatome usually on torso, sometimes on face
Often asymptomatic, lifetime, infection, spread via, body secretions
Herpes simplex 1 & 2
Sexually transmitted, virus causing warts, may lead to cervical cancer
Human Papillomavirus (HPV)
Affects GI mostly, also respiratory, and nervous systems, flu like symptoms
Enterovirus
Virus enters the anterior horn of the spinal cord, damages motor neurons
Poliomyelitis (“polio”)
Starts in upper respiratory (infected droplets), then goes to lower, if immunocompromised life-threatening
Influenza virus
Rhinovirus
“common cold” or upper respiratory tract infection causing inflammation especially in mucosa of nose & throat
Occurs in immunocompromised, a fungus infection of lungs
Fungal Pneumonia (pneumocystis carinii)
Yeast infection, what is the name of the yeast
Yeast infection (Candidiasis)
“Candida albican” = yeast
Cocci (shape)
small spheres
Diplococci (shape)
spheres in pairs
Staphylococci (shape)
spheres in bunches
Streptococci (shape)
spheres in linear groups
Bacilli (shape)
rod shape
Spirochete (shape)
spiral shape
Very common, resides no skin, overgrowth causes disease from mild on severe
Staphylococcus Aureus “staph”
Has two groups Group A and Group B
Streptococcus
Group A: streptococcus pyogenes
Group B: streptococcus agalactiae
Pathologies included in Group A Streptococcus
Invasion of bacteria causing exotoxins, adhesion, colonization & replication activating an innate immune response in bloodstream
Highly contagious throat infection, if left untreated-serious
Pharyngitis – strep throat
If untreated may lead to valve damage
Rheumatic fever
Flesh-eating disease
Necrotizing Fasciitis
Normally occurring bacteria that flourishes in immunocompromised, may cause pneumonia, otitis media, sinusitis, meningitis
Streptococcus Pneumoniae
Sexually transmitted infection of urogenital tract, but may also infect pharynx, eyes, and rectum
Gonococcus (Gonorrhea)
Inflammation of the fluid and the membranes to the meninges
Meningococcal infections
Yersinia pestis
-“The Plague”, “Bubonic Plague”, “Black Death”
-Bacterial infection of lungs
-Transmitted by fleas on rats, fleas bite humans & other mammals & transmit the bacteria
-Causes fever, headache, chills & weakness
Bacteria found in canned food causing blocked nerve functions and severe paralyzing effects
Clostridium Botulinum
Found in water, soil, vegetation, and feces, used to measure quality of water
Coliforms
Example of a bacteria of Coliforms
Escherichia coli (E-coli)
From contaminated water, person dies of dehydration from severe diarrhea
Cholera
Infectious, inflammatory disease of lungs, 1# cause in world for infection, also lymph nodes & other organs affected
Tuberculosis (TB)
Infectious bacterial infection causing skin sores, growths, nerve damage and nasal symptoms
Leprosy
Most common sexually transmitted bacterial infection in the world
Chlamydia
A sexually transmitted protozoa (parasite) infection
Trichomoniasis
1gG, IgM (type of hypersensitivity reaction)
TYPE II
antigens & antibodies deposited (type of hypersensitivity reaction)
TYPE III
T lymphocytes and macrophages (type of hypersensitivity reaction)
TYPE IV
IgE (type of hypersensitivity reaction)
TYPE I
Inhaled pollens trigger a histamine release
Hay fever
Chronic skin irritation, childhood mostly
Atopic dermatitis – ECZEMA
Abnormal response to inhaled allergens in the bronchi
Asthma
A severe life-threatening systemic response to an allergen
Anaphylactic shock
-massive release of histamine
RBCs are destroyed faster than they can be produced
Hemolytic anemia
Antibodies produced attack collagen in the lungs & kidneys
Goodpasture’s Syndrome
Overproduction of thyroid hormones
Hypothyroidism – Grave’s disease
Antibodies attack acetylcholine receptors at the NMJ and there is an excess of cholinesterase, causing an excess of acetylcholine in the cleft
Myasthenia Gravis
Ptosis
Myasthenia Gravis
Ptosis: eyelids droop, face may falsely express sadness & attempts to smile may result in a snarl, impaired vision, difficulty chewing & swallowing, impaired speech often produces sound similar to nasal monotone, head droops forward as result of weak neck mm & fatigue is a frequent complaint
Butterfly rash
Systemic Lupus Erythematosus (SLE)
Renal disease after a sore throat
Post-streptococcal Glomerulonephritis
Antibody/ antigen complexes deposit in small to medium arteries, causing clumping & inflammation
Systemic Lupus Erythematosus (SLE) → pathogenesis
Most common Type IV reaction
Contact Dermatitis
Sexually transmitted virus that infects and destroys CD4 and T Cells
Human Immunodeficiency Virus (HIV)
Abnormal proteins build up in organs causing dysfunction
Amyloidosis
Infection and inflammation of lymphatic vessels
Lymphangitis
Local accumulation of fluid in the interstitial spaces
Edema
Cancer of the lymph node
Lymphoma
Hodgkin’s lymphoma
starts at one single lymph node (often in neck) then progresses to others close by & to other tissues like spleen, liver or bone marrow – two peak incidences:
20’s & 30’s & again in 60’s and 70’s – presence of Reed-Sternberg (RS) cells in lymph nodes is diagnostic
Non-Hodgkin’s lymphoma
mostly from B Cells, more common, also more common in men than women, similar to Hodgkin’s but more widespread & metastasizes early, often well advanced at diagnosis – no RS cells in lymph nodes
Infectious mononucleosis: also called…
Epstein-Barr Virus
Myalgic encephalomyelitis: also called…
Chronic Fatigue Syndrome
List the six attributes of cancer cells
- Anaplasia
- Anchorage Independent
- Lack of Contact Inhibition
- Immortality
- Angiogenesis
- Genetic Instability
benign cancer characteristics
-limited and slow growth
-curable
-encapsulated
-good prognosis
-uniform cell populations
-may compress nearby tissues
malignant cancer characteristics
-enencapsulated
-cells are different from original tissues
-bad prognosis
-uncontrollable growth
-not curable
-considered cancer
3 metastasis routes
- Lymphatic system
- Bloodstream (hematogenous spread)
- Seeding of surfaces of body cavities (close by)
“Oma”
Benign tumors from Mesenchymal cells (from connective tissue, bone & muscles) add “oma”
Fibroma
from fibroblasts
Chondroma
from cartilage
Lipoma
from adipose tissue
Leiomyoma
from smooth muscle
Rhabdomyoma
from striated muscle cells
Osteoma
from bone
Adenoma
epithelial cells (glands & ducts)
“Sarcoma”
Malignant tumors of mesenchymal cells are named from root of cell type plus “sarcoma”
TNM T=, N=, M=
T = size of primary tumor
N = presence/ absence of lymph node involvement
M = distant metastasis
Grading: I=, II=, III=
GRADE I = well differentiated cells (benign)
GRADE II = moderately well differentiated cells
GRADE III = undifferentiated cells (malignant)
4 viral pathologies that are linked to cancer
-Human Papillomavirus (HPV)
-Epstein-Barr Virus (EBV)
-Hepatitis B Virus
-Human T-Cell Lymphoma/leukemia (HTLV)