fighting infection-bacteria Flashcards

1
Q

what allows bacteria to enter and proliferate

A

break in epethial surface

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2
Q

what activates complement pathway and mannon binding lectin pathway leading to cell lysis

A

liposaccharides on the bacteria

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3
Q

three effects of complement

A

1) mast cell activation
2) opsonisation
3) chemotaxis

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4
Q

opsonisation

A

targeted for destruction by phagocytes

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5
Q

after complementation has begun what happens

A

mast cell degranulation causes increased blood flow and leaky blood vessels causing oedema and local irritation

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6
Q

after mast cell degranulation occurs what happens next

A

neutrophils get drawn to sea by complement, bacterial products and chemokine –> adhere to endothelia cell and marginate into infected area

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7
Q

which cells are phagocytksed and killed by neutrophils

A

opsonised bacteria

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8
Q

dendritic cells

A

engul and internalise bacteria- they migrate to the lymph node via the lymphatics

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9
Q

how are naive cells recruited to the lymph nodes

A

recruited by dendritic cells

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10
Q

interaction between dendritic cells and T helper cell in lymph nodes

A

dendritic cells present bacterial peptide to T helper cell receptor on their MHC II molecules which activate the T cells

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11
Q

Dendritic cells can activate

A

T helper 1/2 cells

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12
Q

activated T helper 2 cells cause

A

B cells to become plasma cells and produce antibodies–> initially ism and then class switching occurs and IgG and igA

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13
Q

early antibody production

A

IgM–> 5 binding sites on IgM= enhance binding efficiency

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14
Q

opsonised bacteria engulfed by

A

phagocyte and killed

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15
Q

after infection..

A

bacterial debris is removed by neutrophils or by antibodies as soluble immune complexes

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