Female Reproductive System Flashcards
Primary Sex organs
Gonads
- Ovaries
- -Exocrine - production of gametes (oocyte)
- -Endocrine- production of hormones
Secondary Sex Organs
Internal Genitalia
- Oviducts
- Uterus
- Vagina
External Genitalia
- Vestibule
- Labia minora and majora
- Clitoris
Ovary
Germinal Epithelium (surface of ovary)
- simple cuboidal
- not germ related
Tunica albuginea - CT layer under the germinal epithelium
Cortex
- contains different ovarian follicles in different stages of development
Medulla
- connective tissue and blood vessels
Follicular Development
Primordial Follicles
- flattened follicular cells around it
- born with 2 million, have ~40,000 when puberty hits
- Entered in meiosis
- Arrested in prophase I
FSH begins being produced when puberty hits
- Causes flattened follicular cells to become cuboidal and become granulosa cels
- Becomes Unilaminar Primary follicle (one layer)
Granulosa cells proliferate by mitosis
- become multilaminar primary follicle
- Theca Interna - produces androstenedione (metabolized to estrogen)
Follicle increases in size, antrum space accumulates between granulosa cells
- Becomes Secondary Follicle (antral follicle)
- OMI arrestes follicle in prophase II
- Theca Externa forms - CT layer
Mature (Graffian, tertiary) follicle
- one follicle will ovulate mid cycle
- Granulocytes around oocyte form corona radiata
- Cumulus oophorous also forms
upon ovulation, the OMI in the antral space is dispersed making it unable to arrest oocyte in prophase II
- Oocyte goes to metaphase II and is arrested forever unless fertilization occurs
- Upon fertilization, meiosis occurs
Zona Pellucida
- Thick layer of special proteins that surrounds the oocyte
- CT layer
- Stay around oocyte forever unless fertilization occurs
Corona Radiata
- Layer of tightly packed granulosa cells around the zona pellucida
Theca Interna
- produces androstenedione
- which gets converted to estrogen
- Abundant number of lipid droplets
- Smooth ER (steroid producing)
- mitochondria with tubular cristae
-
Atretic Follicle
- Oocyte is no longer oval shaped
- Granulosa cells become pignoitc
- Follicles with inappropriate crossing over are selected out
- wouldn’t lead to a normal functioning baby
Graffian Follicle
- produces estrogen from granulosa cells
- and androstenedione from the theca interna
- When oocyte is released, the graffian follicle becomes the corpus luteum
Corpus Luteum
Granulosa cells become granulosa lutein cells
- produce progesterone
Theca interna cells become theca lutein cells
- produce estrogen
- only lasts 12 days, for the second half of the cycle
- regresses, leaving behind corpus albicans (least degradable material)
Oviduct
- Uterine tube or Fallopian tube
Parts
- Fimbriae (finger like projections) - bring oocyte into the infundibulum
- Infundibulum
- Ampulla (wider area)
- Isthmus (more narrow)
- Pars interstialis - where it passes into the uterus
Fertilization occurs in the ampulla
- Zygote may then go and implant into the wall of the uterus
Ectopic Pregnancy
- Small zygote implants in the wall of the oviduct
- As it gets larger, diffusion becomes rate limiting
- Starts to break down and become necrotic
- If not removed, it can rupture the wall of the oviduct and woman could bleed out
Histology of Oviduct
- Lined by mucosa of epithelial cells
- mucosa is thrown into folds
- ampulla is highly folded
2 layers of muscle
- inner circular
- outer longitudinal muscularis
- outer serosa - CT layer
- continuous with broad ligament of abdominal cavity
Cells of Oviduct
Secretory cells
- secrete mixture of fluids and proteins (transudate) to provide nutrients for oocyte or sperm that might be there
Ciliated cells
- under the influence of estrogen
- facilitate the movement of oocyte down oviduct and towards uterus
Uterus
Fundus
- part of the uterus above where the oviduct comes in
Body=Corpus
Cervix - tip of the uterus
- gate keeper
Uterus is where implantation of the zygote occurs
3 Layers of Uterus
- endometrium
- Glandular layer (highly folded glands)
- Shed each month during menstrual cycle - Myometrium (middle)
- smooth muscle layer
- Thickest layer - Perimetrium
- CT layer
- Continuous with the broad ligament of abdominal cavity
Endometrium
Basalis
- small layer of endometrium that remain during menstruation
- Arcuate arteries underneath basalis pass through the basalis as straight arteries
Functionalis
- Part of endometrium that changes through menstruation
- there are coiled arteries here
- go from tubular to coiled in the second half of the cycle
Menstrual Cycle
Day 1 (or 0)
- first day of menstruation
- LH and FSH are being secreted by pituitary
- FSH has an effect on granulosa cells of the follicle causing them to produce estrogen
Increasing in Estrogen
- promotes proliferation of endometrium (starts to grow back)
- Estrogen levels increase, negatively feedbacks on FSH secretion
Mid Cycle - Surge in Estrogen
- Causes a surge in FSH and LH from pituitary
LH causes rupture of follicle to release oocyte= ovulation
Corpus luteum
- producing large amounts of progesterone and estrogen
- goes into secretory phase
- causes increase in vasculature of endometrium
After 12 days, things start to break down, hormone levels start to decline
Go back to day 1 (or 0)
Progesterone
- During secretory phase, high levels of progesterone prevent multiple ovulation (further follicular development)
- also reduces ciliary motion in oviduct, and increases cervical viscosity
- birth control promotes high levels of progesterone
Fertilization
- Ovulation occurs mid cycle
- Fertilization occurs in the ampulla
- Takes about a week for zygote to reach the uterus
- uterus would be in secretory phse
- if embryo is formed, it produces hCG
- mimics LH, maintains the endometrium so that it doesn’t shed which helps provide nutrients and maintains developing zygote in the wall of the uterus
- eventually with the development of the placenta, it will take over the production of the hCG
Cervix
Layer of simple columnar thrown into folds
- highly secretory
- secretes viscous fluid to prevent foreign pathogens, bacteria, viruses and sperm from getting into the uterus
Right around mid cycle, the fluid changes from viscous to aqueous to help facilitate sperm to get in - for fertilization
- simple columnar transitions to stratified squamous non keratinzied as it transitions to vagina
Vagina
Mucosal Lining
- stratified squamous non keratinized epithelium
- lamina propria
Vaginal Muscularis
- smooth muscle thrown into folds
Serosa CT layer on the outside
Skene Gland
- secretes lubricating fluid
- tubular alveolar Gland lined by simple columnar epithelium
- homologous to the prostate gland
Bartholins Gland
- secretes a mucous fluid for lubrication
- Tubular alveolar glands lined by simple columnar epithelium
- homologous to bulbourethral glands
