Female GU/Breast (Week 3) Flashcards

1
Q

True or False?

Most breast pathology arises in the terminal duct lobular unit?

A

True

This is where the lobules and ducts branch

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2
Q

Define dysplasia

A

This is somewhere on the spectrum between normal tissue and non-invasive malignancy tissue
(But is NOT cancer)

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3
Q

Which of the following is NOT an inflammatory breast condition?

A) Acute mastitis
B) Fat necrosis
C) Ectopic breast tissue
D) Granulomatous conditions

A

C)

Ectopic breast tissue is a developmental condition

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4
Q

Small aggregates of which substance commonly form in fibrocystic change of breasts?

A

Calcium

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5
Q

What feature can be used to differentiate radical scar from breast cancer?

A

Myoepithelial cells are present in radical scar but not in breast cancer

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6
Q

Name 2 benign neoplasms of the breast

A

Fibroadenoma (firm mobile lump)
and
Intarduct papilloma

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7
Q

Between which ages does breast screening occur and how often?

A

For women aged between 50-70 every three years

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8
Q

What is meant by ‘sentinel node’?

A

The node in the axilla that cancer will likely spread to first

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9
Q

What does ‘carcinoma in-situ’ mean in terms of breast pathology?

A

This is another term for dysplastic breast tissue and can be ductal (DCIS) or lobular (LCIS)

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10
Q

In the TNM staging of breast cancer, what does TNM stand for?

A

T: tumour size in mm
N: how many axially nodes affected
M: metastasis?

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11
Q

What type of epithelium lines the ectocervix?

A

Stratified squamous non-keratinising

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12
Q

Which area of the female genital tract is lined by Columnar epithelium?

A

Endocervix

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13
Q

Which 2 strains of HPV are prevalent in Scotland?

A

HPV 16 and 18

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14
Q

Between which ages and how often is cervical screening carried out in Scotland?

A

25-50 every 3 years

50-65 every 5 years

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15
Q

Define koilocytosis

A

A change in epithelial cells after infection with HPV

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16
Q

Name the condition which involved non-infective inflammation of the vulva

A

Lichen plantus
or
Lichen sclerosus et atrophicus

17
Q

During development, what does the fused portion of the Mullerian duct and urogenital sinus go on to form?

A

Uterus

18
Q

Define the condition ‘adenomyosis’

A

The presence of endometrial tissue in the myometrium

19
Q

Hyperplasia and adenocarcinoma of the endometrium is commonly associated with prolonged stimulation by which hormone?

A

Oestrogen

20
Q

What is a leiomyoma?

A

Benign tumour of the myometrium

21
Q

What is the name given to a malignant tumour of the myometrium?

A

Leiomyosarcoma

22
Q

What is meant by a ‘complete molar pregnancy’

A

An egg with no genetic material is fertilised by one sperm which duplicates its chromosomal material

23
Q

In the non-keratinising stratified squamous epithelium of the ectocervix and vagina, where are most dividing cells located?

A

Division occurs just above the basal layer, before cells migrate upwards while maturing and accumulating glycogen

24
Q

What are endometriomas (chocolate cysts)?

A

Endometriosis in the ovaries causing blood filled cysts

25
Q

Which mutations are associated with low grade serous carcinomas?

A

BRAF and KRAS mutations

26
Q

P53 and BRCA mutations are associated with which type of ovarian cancer?

A

High grade serious carcinoma

27
Q

Which cysts are formed by the proliferation of cells surrounding an oocyte?

A

Follicular and luteal cysts

28
Q

Give an example of an alkylating agent chemotherapy drug

A

Melphalan (for multiple myeloma, ovarian and breast cancers)

29
Q

How does the antimetabolite drug ‘Flurouracil’ work?

A

This IV drug prevents thymine formation which disrupts DNA synthesis

30
Q

What is the mechanism of action of microtubule inhibitor drugs as chemotherapy agents?

A

Bind to microtubules to block tubular polymerisation, preventing spindle formation and altering cell division