Cardiology (Week 5) Flashcards
Name two main features that characterise heart failure?
Systemic vasoconstriction and neurohumoral activation
List three causes of heart failure
- MI
- Hypertension
- Idiopathic
- Alcohol
- Chemotherapy
Name a common sign of heart failure
Displaced apex beat
3rd heart sound
Elevated JVP
What class of drugs are used for symptomatic relief in heart failure but do not improve outcomes
Diuretics
What does a neprilysin inhibitor do in terms of heart failure treatment?
Inhibits neprilysin, an enzyme which breaks down natriuretic peptides whose function is to cause vasodilation and diuresis (maintain this as is beneficial to HF)
Why should ACE inhibitors and angiotensin receptor blockers never be given together?
Because they both prevent the breakdown of bradykinin which causes cough and angioedema
What do low natriuretic peptides mean in terms of heart failure diagnosis?
That the patient does not have heart failure
What are Kerley B lines?
Fluid moving into the interstitial space and causing pressure build up in vessel s, appearing as small, white straight lines on the edge of chest X-ray
How does alveolar oedema present on chest X-ray and what is it indicative of?
Appears as fluffy white surrounding black tubes in the lungs and is a late sign of heart failure
In which condition would the loss of costophrenic angles be seen on chest X-ray?
Pleural effusion
What is the definition of myocardial infarction?
Elevated troponin in a clinical setting consistent with myocardial ischaemia
What is the difference between type 1 and type 2 MI?
Type 1 is due to plaque rupture and thrombus formation
whereas
Type 2 is due to increased oxygen demand or decreased oxygen supply
Describe unstable angina
An acute coronary event without a rise in troponin
What does ST elevation in MI indicate?
Coronary artery occlusion
Name the three types of atrial fibrillation in order of increasing duration?
Paroxysmal
Peristsent
Permanent