Familial Breast Cancer

Question 1

What % of breast cancers are due to inherited fault in gene?

Answer 1

5%

Question 2

What is the BRCA inheritance pattern?

Answer 2

Autosomal Dominant
(affects men too!)

BRCA1 and BRCA 2 genes

Question 3

What considerations must be taken during history taking when suspecting BRCA mutations?

Answer 3

• Need maternal and paternal family history
• More prevalent in Ashkenazi Jews
• Risk of BC still increases with age

Question 4

What is the absolute lifetime risk if BRCA +ve

Answer 4

WOMEN
50-80% risk of BC/ ovarian cancer

MEN
10-20% risk of BC

Question 5

What management is done when suspected BRCA +ve?

Answer 5

Screening

• Family members may be screened IF disease-mutation has been identified in an affected family member
• Mammogram then alternating with MRI (reduce radiaiton exposure)

SURGICAL
Prophylatic Mastectomy
Prophylatic Oophrectomy