✅F3 (PEDS/PREGNANCY/REPRO/UROLOGY/BREAST) Flashcards
Give brief descriptions of each pediatric neoplasm
Neuroblastoma
________________
Rhabdomyosarcoma
________________
Wilms tumor
N: extracranial solid tumor of adrenal medulla p/w catecholamine sx: HTN, flushing sweating
___________________
R: malignant soft-tissue tumor of the head/neck
___________________
W: most common ped renal CA presenting < 5 yo with uL PAINFUL abd mass + Hematuria + HTN
N/W mass compresses renal artery ➜ activates renin-angiotensin system ➜ HTN
initial tx for Insomnia
CBT
_________________
sleep hygiene / sleep restriction / relaxation techniques
MDD and Grief have overlapping Symptoms
What are 3 factors of Grief that separate it from Major Depression Disorder?
grief (normal rxn to loss):
Intensity ⬇︎ over time
Suicidality NOT common
“waves” of grief at reminders
Clozapine’s SE is agranulocytosis
Name the Granulocytes - 3
BEN
Basophils
Eosinophils
Neutrophils
Clozapine also causes Metabolic Syndrome X, Seizures and Myocarditis
Diagnostic criteria for Persistent Depressive Dysthymia disorder - 3
- at least 2 / 6 of SIgeca
- CONSTANT ≥ 2 years (or 1 year in kids)
- No relief > 2 mo
Major Depressive Episodes may also occur with this
Vulvodynia cp
________________
tx -2
≥3 mo idiopathic raw burning vulvar pain
________________
Tx = [pelvic floor physiotherapy] and CBT
Exercise during pregnancy ⬇︎ risk of (⬜3)
gestational DM
PreEclampsia
Cesarean
What are the contraindications to Exercise during pregnancy? -3
- cervical insufficiency
- underlying comorbidity preventing exercise
- active vaginal bleeding
How do you manage Patient agitation when it’s escolated to violence? -2
- PHYSICAL RESTRAINTS
- INTRAMUSCULAR ANTIPSYCHOTIC
[Pyogenic granuloma telangiectaticum]
[dome shaped papule with recurrent bleeding] caused by capillary proliferation after trauma during pregnancy
Describe [Simple breast cyst]
________________
benign fluid filled mass 2/2 breast duct obstruction
________________
What are the risk factors for Cervical Insufficiency? -4
- Cervical Conization
- Uterine abnl
- Prior obstretric trauma
- congenital (intrauterine DES exposure, collagen abnl)
Rett syndrome sx -3
- [microcephaly with developmental regression]
- epilepsy
- unique hand gestures
patient is diagnosed with breast cyst
Describe your workup -5
What level of prolactin indicates a Prolactinoma
>200
Prolactin inhibits LH release
Name the factors of Schizophrenia a/w a good prognosis -6
Febrile seizures present day ⬜ of illness, are a common complication of high fever a/w ⬜, and onset between ⬜ y/o
_________________
What is the prognosis for children with febrile seizure
1 ; viral infection ; [3 months - 6 yo]
_________________
typically [benign course (does not require tx)] but 30% will have ≥1 recurrence and also have INC risk for Epilepsy
How do you treat Febrile Seizure? -3
- REASSURANCE
- [Abortive tx if ≥5 min]
- [Sx Tx (APAP)]
A physician (⬜ can | cannot) unilterally terminate a patient solely for nonpayment \_\_\_\_\_\_\_\_\_\_\_\_\_\_\_\_\_ When is a physician considered "abandoning" a patient? -2
CAN
_________________
Abandoning Patient if:
- Patient terminated whilst in immediate medical need
- Patient NOT given reasonable time to find alternate provider
AntiParkinson tx can cause psychosis due to ⬜
How do you manage this? -2
+ dopaminergic effects (activation of mesolimbic pathway)
_________________
[DEC AntiParkinson dosage (starting with least potent)]
–(if sx persist)–> [add D2 R Blocker (Quetiapine/Clozapine/PimaVanserin)]
What are 2 major signs of tooth decay?
_________________
Name 3 risk factors for a baby developing tooth decay?
white spots / discoloration
_________________
- sugary substances frequently
- nighttime bottle/feedings
- Inadequate fluoride
* Dental Home must be established by 1 y/o*
What are the 4 major risk factors for [Spontaneous Abortion < 20WG]?
PREVIOUS SPONTANEOUS ABORTION
[Maternal Age > 35]
[Maternal Substance Use]
[BMI extremes]
Describe the following contraception:
a. Progestin-releasing IUD
_________________
b. Copper-containing IUD
_________________
c. BL tubal Ligation
a. long,reversible contraception used in pts with contraindication to estrogen. Also ⬇︎menstrual blood loss in anticoagulated pts
_________________
b. long, reversible contraception but ⇪ menestrual bleeding and dysmenorrhea
_________________
c. irreversible contraception indicated for pts finished with childbearing. Will NOT help menorrhagia
Ovarian torsion occurs in ⬜ women and presents with (⬜2 sx)
_________________
how do you diagnose this?
reproductive ; [uL pelvic pain + tender adnexal mass]
_________________
[Pelvic Ultrasound with color Doppler]
(will show enlarged edematous ovary with ⬇︎blood flow)
Main features of Becker Muscular Dystrophy - 4
- [Xp21 deletion] (X-link recessive deletion on Chromo Xp21)
- Scoliosis
- [peds onset at 5 yo]
- [cardiomyopathy ➜ 40-50 yo DEATH]
Main features of Duchenne Muscular Dystrophy - 5
- [CALF PSEUDOHYPERTROPHY requiring gower manuever + teenage wheelchair] = [⇪ Creatine Kinase]
- [Xp21 deletion] (X-link recessive deletion on Chromo Xp21)
- Scoliosis
- [peds onset at 2 yo]
- [cardiomyopathy ➜ 20-30 yo DEATH]
Why are the Negative symptoms of Schizophrenia treated differently?
and what are Negative Schizo sx treated with?
NEGATIVE Schizo Sx respond poorly to Antipsychotics so…
_________________
➜ Negative Schizo symptom tx = [social skills training]
For Women who wish to preserve fertility:
What is the MOA for the 1st line tx of [Leiomyoma Fibroids]
_________________
Whats another tx for this?
[Progestin-releasing IUD] Reversibly induces endometrial atrophy ➜ [⬇︎ leiomyoma size and ⬇︎ uterine bleeding]
_________________
[Combined OCP]
What are the sx of [Leiomyoma Fibroids] -4
enlarged irregularly shaped uterus
regular menorrhagia
dysmenorrhea
mass effect (constipation/pelvic pressure/urinary sx)
In neonates, how might Cystic Fibrosis present? -4
Meconium iLeus = inspissated GI secretions obstruct meconium excretion in distal iLeum ➜
[DILATED SMALL BOWEL LOOPS with NARROW UNDERUSED MICROCOLON]
[Bilious emesis]
[R ground glass mass AXR (from iLeum air mixing with iLeum meconium)]
_________________
AXR = Abdominal XRay
ASK ABOUT FAM HX OF RECURRENT SINUS INFECTIONS
Diagnosis? ; Name the major risk factor for this
HIRSCHSPRUNG DISEASE ; [Mom ≥ 35 yo]
markedly dilated descending colon
[Advanced Maternal Age ≥35] is a risk factor for ⬜, which is a/w with what 2 neonatal conditions?
Down Syndrome Trisomy 21
_________________
Duodenal Atresia (double bubble)
Hirschsprung disease (dilated colon)
Maternal Macrolide use during pregnancy is a risk factor for ⬜ , which typically presents at age ⬜ with (⬜2)
[pyloric stenosis] ; 1 month old ;
NONBILIOUS PROJECTILE VOMITING + PALPABLE OLIVE SHAPED ABD MASS (target sign on XR)
What is the Doctrine of Implied Consent?
pts who LACK DECISION-MAKING CAPACITY
but REQUIRE 911 TX
may be given (wihout their explicit consent) same tx most reasonable people in a similar siutation would expect to receive
Physicians should screen for ⬜ in veterans reporting insomnia, substance use and interpersonal conflict
________________
Tx for this condition? -3
PTSD
________________
[Trauma Focused CBT]
[SSRI/SNRI]
[Prazosin for nightmares]
Physicians should screen for ⬜ in veterans reporting insomnia, substance use and interpersonal conflict longer than ⬜
________________
What is the diagnostic criteria -2
PTSD
> 1 month
________________
[LIFE THREATENING TRAUMA]
+
P.A.I.N. sx
________________
Pysch (sleep ∆ /hypervigilance/concentration ⬇︎)
Avoidance (avoids distressing thoughts/feelings/external reminds of the event)
Intrustion (nightmares/flashbacks)
Negative mood (guilt/ anhedonia/detachment/anger/self-esteem ⬇︎)
how does Nephrolithiasis present during pregnancy?
_________________
dx?
2nd or 3rd trimester
[Flank pain that radiates to labia + NV]
_________________
dx = renal/pelvic US
What are the recommendations regarding Bariatric Surgery and Pregnancy?
After Bariatric Surgery, Delay Pregnancy x 1 year to optimize wt loss and nutrition
BP Goal for Pregnant patients?
< 140/90
patients with fetal growth restriction (defined as ⬜ ) are at ⇪ risk for ⬜
_________________
How is this managed?
[estimated fetal wt < 10th%tile for gestational age]; STILLBIRTH
_________________
[Serial Antenatal testing]
What is the purpose of [Fetal Fibronectin test]?
determines risk of preterm delivery in patients with preterm contractions
Describe purpose of [Percutaneous Umbilical Sampling]
high risk procedure that samples fetal blood to confirm severe fatal anemia (hydrops fetalis)
What’s current recommendation regarding Lyme disease during Pregnancy?
_________________
Which 2 abx can be used to treat Lyme disease during Pregnancy?
If mother receive adequate abx (PO amoxicillin vs PO ceFUROxime) = NO ⇪ FETAL RISK
AFP is obtained in pregnant women at 15-20WG
________________
What does an elevated AFP indicate in a pregnant woman?-3
- Fetal Open Neural Tube Defects (open spina bifida, anencephaly)
- Fetal Abd Wall defect (Gastroschisis, Omphalocele)
- Multiple gestation (twins)
If ⬆︎AFP –> GET ANATOMY US!
What is the Prenatal Maternal Quad Serum screening? When is this obtained?
Measures 4 chemical markers for fetal anomalies and down syndrome- 81% accuracy (QUAD = BUAD):
- βHCG⬆︎
- Unconjugated EsTriol⬇︎
- AFP⬇︎
- Dimeric inhibin A⬆︎ - only in QUAD screen
Performed 15 -20WG
Be sure to f/u abnml results with cell free fetal DNA test and US
What are the Quad BUAD results (obtained 15-20WG) for Edward’s Trisomy 18?
⬇︎βHCG
⬇︎Unconjugated EsTriol
⬇︎AFP
NML Dimeric inhibin A
AFP (from Maternal serum) is a protein made by the (⬜3) It is obtained in pregnant women at ⬜ weeks gestation via ⬜
_________________
What constitutes as an elevated AFP?
[Fetal Yolk Sac]/GI/Liver
________________
15-20WG
________________
via Quad BUAD screen
if AFP > 2.5 ➜ get anatomical US!
What 2 contraceptives are the most ideal for adolescents teens? Why is this?
[IUD or subdermal implants] = RELIABLE, SAFE and REVERSIBLE
long acting reversible contraceptives
Pt on Valproate, incidentally found to be 14 WG
How do you manage this?
although [AntiEpileptics Drugs] (especially valproate) are INC risk for congenital anomalies
DO NOT MAKE CHANGES TO AED AFTER CONFIRMATION OF PREGNANCY
Instead ➜ start pt on [high dose folic acid] + [obtain AFP with anatomical US] to screen for congenital anomalies
[T or F]
[AntiEpileptic Drugs] are relatively contraindicated with breastfeeding
FALSE
_________________
Moms CAN breastfeed while on [AntiEpileptic Drugs]
Name the absolute contraindications to breastfeeding? - 7
BITCHES can NOT breastfeed!
- [Breast has HSV lesions]
- [Infant has galactosemia]
- TB untreated
- Chemoradiation
- HIV maternally
- varicElla actively
-
Substance abuse maternally
* Hep B pts can breastfeed as long as baby receives HepB Immunoglobulin and vaccination*
Peds with untreated iron deficiency anemia are at INC risk for what 2 comorbidites?
___________________
How is this mitigated? -3
psychomotor delay
neurocognitive impairment
_________________
[universal screening starts age 1 yo]
–(if hgb <11)–> [PO ferrous sulfate]
_________________
IDA is the most common nutritional deficiency in kids
Explain why some females have irregular heavy menstruation around menarche
_________________
endometrium builds 2/2 estrogen, however, without progesterone (common around menarche) the cue to slough endometrium is absent = Anovulation➜ estrogen breakthrough bleeding = irregular heavy menstruation
_________________
Estrogen proliferates and repairs Endometrium ➜ Endometrial hemostasis
Name the causes of [Abnormal Uterine Bleeding] in nonpregnant women? -9
_________________
How do you treat ACUTE heavy [Abnormal Uterine Bleeding]?-3
__________________
- HDS*: [combined OCP with HIGH DOSE ESTROGEN]
- NPO/Refractory*: [IV Estrogen]
- HDUS*: [D&C (endometrium surgical removal)]
_________________
Estrogen proliferates and repairs Endometrium ➜ hemostasis
What is Pubic Symphsis Diastasis? ; What is the clinical presentation of this after a traumatic delivery?
Physiological widening of pelvis by progesterone and relaxin to facilitate vaginal delivery ; Postpartum suprapubic TTP pain that radiates to the Back and/or Hips
worst with weight bearing, walking or position change and resolves by 4 weeks PostPartum
CP for Endometriosis - 5
The 3 Ds and All
- Dysmenorrhea
- Dyspareunia deep pelvic - implants in posterior cul-de-sac
- Dyschezia (painful defecation) - implants in posterior cul-de-sac
OR
(4) ASX (tx not indicated if so) - otherwise tx = NSAIDs –> Contraceptives (combined OCP/IUD progesterone)
(5) Infertility of unknown origin
* Findings: Gun Powder Burn lesions, ADHESIONS–>immobile uterus, Chocolate fluid*
* Dx = Laparoscopy to biopsy & remove endometriotic lesions*
Why is it common for adolescents to have irregular and anovulatory menstruation?
immaturity of hypothalamic-pituitary-gonadal axis –> inadequate amounts of GnRH –> low FSH and LH –> lack of ovulation –> lack of Menses
Menses normally occurs when corpus lutem (byproduct after ovulation) produces progesterone and this progesterone drops –> Menses/shedding. No ovulation –> No menses
- Tx = Progestin-only or Combined OCPs*
- this self-resovles 1-4 yrs after menarche*
hCG is secreted by _____ and responsible for what? ; When does hCG production begin?
syncytiotrophoblast ; preserves corpus luteum (which secretes progesterone) during early pregnancy until the placenta can take over ; 8 days after fertilization
hCG also stimulates maternal thyroid and promotes male sex differentiation
Which hormone prepares the endometrium for implantation of a fertilized egg?
Progesterone Prepares endometrium via decidualization
MOD for PCOS
Hyperinsulinemia and Elevated LH –> ⬆︎ Androgen release from Ovarian Theca which is converted to Estrone–> Elevated Estrone which feedbacks on the hypothalamus –> ⬇︎GnRH –> ⬇︎FSH imbalance –> failure of follicle maturation and anovulation –> No progesterone –> Endometrial CA
- tx = weight loss and clomiphene citrate*
- Note: if pt has high levels of sex hormone binding globulin, total testosterone may be low. so clinical dx may be necessary*
Tenderness along the uterosacral ligament should make you suspicious for what disorder?
Endometriosis
Which hormone induces prolactin production during pregnancy?
Estrogen
Which hormone is responsible for myometrium relaxation during pregnancy?
Progesterone
After giving abx
How do you manage UTI in peds less than 2 yo
_________________
what about peds > 2 yo?
after 1st febrile UTI,
in [peds < 2 yo]= renal/bladder US (to evaluate for anatomic abnl) –(if abnl)–>VCUG
_________________
[peds > 2 yo] = No imaging as long as abx tx ➜ resolution
VSUG = voiding cystourethrogram
How do you manage a pregnant patient who’s GBS positive at 14 WG? -2
[Amoxicillin or Cephalexin STAT] + [PCN intrapartum]
_________________
pregnant patients require abx STAT to prevent progression to upper UTI (like
Tx for Lichen Sclerosis
Clobetasol ointment (high potency topical CTS)
dx = vulvar punch biopsy
clinical presentation of [Genital wart condyloma acuminata]
_________________
Tx?
cauliflower-like, soft and raised lesions
_________________
TriChloroAcetic acid