F. Benzodiazepines Flashcards

1
Q

Benzodiazepinen (voorbeelden)

A

Temazepam, T1/2 7-11 uur
Oxazepam, T1/2 4-15 uur
Diazepam, T1/2 40-100 uur

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2
Q

Benzodiazepinen (werkingsmechanisme)

A

Versterken de remmende werking van GABA.

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3
Q

Benzodiazepinen (indicaties)

A

Slaapstoornissen (temazepam)
Gegeneraliseerde angststoornissen
Behandeling van onthoudingsverschijnselen
Behandeling koortsconvulsie/epileptisch insult
Premedicatie bij chirurgische ingrepen

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4
Q

Behandeling alcoholonttrekking

A

Thiamine en benzodiazepine

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5
Q

Benzodiazepinen (bijwerkingen)

A

Spierhypotonie (valneiging)
Amnesie
Verminderde alertheid
Tolerantie
Afhankelijkheid
Ademdepressie

Paradoxale reactie (agitatie, onrust) bij kinderen of ouderen

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6
Q

Benzodiazepinen (interacties)

A

Antihypertensiva: valneiging
Opiaten: valneiging

Alcoholgebruik: valneiging
Ouderen: valneiging

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7
Q

Benzodiazepine-receptoragonist

A

Flumazenil (T1/2 1 uur)

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