Extras: Summary Sheets

Question 1

sedative drugs major action

Answer 1

increase GABA interactions

Question 2

two benzos for insomnia + their AE

Answer 2

temazepam, triazolam; cause anterograde amnesia

Question 3

what sedative class crosses placenta and causes respiratory depression in fetus + are classic CYP3A4 inducers?

Answer 3

barbiturates

Question 4

barbiturate that treats SZRs

Answer 4

phenobarbital

Question 5

issue with ramelteon

Answer 5

<50% of pts see results

Question 6

issue with suvorexant

Answer 6

next-day somnolence, some complex sleep behaviors

Question 7

which sedative is only for sleep maintenance issues, not sleep onset issues?

Answer 7

doxepin

Question 8

four classes of opioids

Answer 8

1. phenylpiperidines
2. diphenylheptanes
3. phenanthrenes
4. benzomorphans

Question 9

loperamide targets what receptors?

Answer 9

mu opioid receptors in GI tract

Question 10

four opioid partial agonists

Answer 10

1. pentazocine
2. buprenorphine
3. nalbuphine
4. butorphanol

Question 11

pentazocine use

Answer 11

pre-op supplement to anesthesia

Question 12

what strucutral class are naloxone and naltrexone?

Answer 12

phenanthrenes

Question 13

naltrexone has highest affinity at what receptor?

Answer 13

mu opioid receptor

Question 14

scheduled drugs: which one is the worst vs the most chill?

Answer 14

schedule I is worst (no medical use, just recreational drug with high abuse potential), schedule 4 is the mildest

Question 15

two SSRIs with a second function of being partial/full agonists to the 5HT receptors

Answer 15

Vilazodone, Vortioxetine

Question 16

what SSRI is most anti-cholinergic of the group and what does that mean for its use?

Answer 16

Paroxetene -> dont give to elderly pts

Question 17

what SNRI also has actions on DA, making it an anti-psychotic?

Answer 17

amoxapine

Question 18

3 C’s of TCA OD

Answer 18

coma, convulsions, conduction abnlts

Question 19

TCAs are SNRI’s that also affect what other three receptors?

Answer 19

Histamine, muscarinic, a1 adrenergic

Question 20

three receptors blocked by SARAs

Answer 20

a1 adrenergics, 5HT, H1

Question 21

major AE of SARAs

Answer 21

sedation

Question 22

which SARA causes hepatic toxicity

Answer 22

Nefazodone

Question 23

which drug class causes hypertensive crisis and why

Answer 23

MAOIs: block MAO A -> tyramine cant be broken down -> tyramine causes catecholamine release -> HTN

Question 24

what drug type is Buproprion

Answer 24

NDRI

Question 25

what does Esketamine do?

Answer 25

NMDA receptor antagonist

Question 26

one drug specifically for post-partum depression

Answer 26

Brexanolone

Question 27

mnemonic for anti-depressant withdrawal

Answer 27

FINISH: flu-like, insomnia, nausea, imbalance, sensory sx (parasthesias), hyperarousal

Question 28

which bipolar drug is only used for maintenance, not acute mania?

Answer 28

lamotrigine

Question 29

which AED for bipolar induces hepatic UGT while the other ones inhibit it?

Answer 29

Carbamazepine

Question 30

amphetamine-based stimulants: liquid, IR vs ER drug

Answer 30

liquid IR: Detroamphetamine sulfate | liquid ER: amphetamine

Question 31

amphetamine based stimulant that is ER & ODT

Answer 31

adzenys

Question 32

Daytrana patch is what drug?

Answer 32

methylphenidate

Question 33

two AEs with atomoxetine

Answer 33

liver injury, SI**

Question 34

atomoxetine vs guanfacine & clonidine MOAs

Answer 34

1. atomoxetine: inhibits NE reuptake | 2. guanfacine/clonidine: a2 adrenergic agonists in PFC

Question 35

two withdrawals that can be deadly

Answer 35

alcohol, barbiturates/sedatives

Question 36

treating HTN and hyperthermia in a pt on meth or coke

Answer 36

phentolamine

Question 37

MOA of cocaine

Answer 37

inhibits DA reuptake

Question 38

drug for pt on LSD or PCP

Answer 38

diazepam

Question 39

only rec drug where pupils are constricted with use

Answer 39

opioids / heroin

Question 40

treating HTN in a pt in opioid withdrawal

Answer 40

clonidine

Question 41

acamprosate MOA

Answer 41

NMDA antag + GABA R agonist

Question 42

FGAs vs SGAs MOA

Answer 42

1. FGA: D2 R blocker | 2. SGA: block 5HT > D2

Question 43

which FGA causes torsades de pointes

Answer 43

Thioridazine

Question 44

what drug class can cause NMS (neuroleptic malignant syndrome)

Answer 44

SGAs

Question 45

two SGAs notable for prolactin sx

Answer 45

iloperidone, risperidone

Question 46

SGA notable for QT prolongation/EKG changes

Answer 46

Ziprasidone

Question 47

two SGAs notable for WG, glucose/lipid increase

Answer 47

Clozapine, Olanzapine

Question 48

SGA specifically for Parkinson's psychosis

Answer 48

Pimavanserin

Question 49

three drugs to treat dystonia from anti-psychotics***

Answer 49

Benztropine, Benadryl, Triheyxphenidyl

Question 50

three drugs to treat akathisia from anti-pschotics

Answer 50

BB (propanolol), Benzodiazepine, Benztropine

Question 51

two drugs to treat parkinsonism from anti-psychotics

Answer 51

benztropine, amantidine

Question 52

drug type that treats tardive dyskinesia from anti-psychotics, + two examples

Answer 52

VMAT2 inhibitors; Valbenazine & Deutetrabenazine

Question 53

anti-psychotics: 4 for acute agitaiton + 4 for long acting injectables

Answer 53

1. Acute: HOAZ: Haloperidol, Olanzapine, Aripiprazole, Ziprasidone 2. Long-Acting: ROAP: Risperidone, Olanzapine, Aripiprazole, Paliperidone

Question 54

what drug type to avoid in elderly hospitalized pts to avoid delirium

Answer 54

benzos

Question 55

two types of ADHD

Answer 55

inattentive type, hyperactive type