41: Mood Disorders Flashcards
genetics with mood disorders
25% of pts with a mood DO have a first degree relative with a mood DO, and 50% of pts with bipolar DO have a first degree relative with a mood DO
four nts that are decreased in depression
norep, dopamine, serotonin, GABA
what nt is increased in mania?
dopamine
what is NMDA a receptor for?
glutamate
how does ECT work?
induces a seizure, but is very safe and effective
common AE of ECT
short term memory loss
TMS: compared to ECT
less effective, but same in the fact that there are basically no AEs
what can ECT and TMS be used to treat?
Depression, OCD, migraines, smoking cessation
where does TMS target in the brain?
prefrontal cortex
what does ketamine help treat?
SI and depression
OD on ketamine looks like…
panic attacks, aggressive behaior, increased ICP, cardiac arrest
what drug is ketamine similar to?
PCP
what receptor does ketamine act on?
NMDA
spravato
Esketamine, used for tx-resistant depression as a rapid-acting nasal spray
conditions that can be helped by psilocybin
end-of-life anxiety and depression, addictions, OCD, major depression
