40: Anti-Depressants and Mood Stabilizers

Question 1

anti-depressants can also be used to treat…

Answer 1

1. anxiety, panic disorder
2. PTSD
3. OCD
4. PMDD

Question 2

buproprion can also be used to treat…

Answer 2

nicotine withdrawal

Question 3

imipramine can also be used to treat…

Answer 3

enuresis

Question 4

duloetine can also be used to treat…

Answer 4

diabetic peripheral neuropathy, fibromyalgia, chronic pain + stress incontinence

Question 5

“response” to anti-depressants

Answer 5

50%+ reduction in sx from baseline

Question 6

remission vs recovery

Answer 6

remission: sx free
recovery: 6-12 months ongoing remission

Question 7

relapse vs recurrence

Answer 7

1. relapse: return of sx after remission, before recovery

2. recurrence: return of sx after recovery

Question 8

most pts see response to anti-depressants in how long?

Answer 8

3-4 weeks

Question 9

what % of pts can reach remission on just a single anti-depressive agent

Answer 9

20-35%

Question 10

symptoms of hypertensive crisis

Answer 10

severe HA, sweating, anxiety, nosebleeds, tachy, CP, change in vision, SOA, confusion, N/V

Question 11

how does the kidney handle lithium

Answer 11

Li competes with Na for reabsorption -> Na not reabsorbed as much

Question 12

Li effect on ADH

Answer 12

Li enters principle cells of collecting ducts via Na channels -> accumulate -> interfere with ADH -> ADH resistance -> polyuria and polydipsia