Extras: Diarrhea And Constipation Drugs Flashcards
3 Opioid agonists + 3 antagonists
Agonists: loperamide, eluxadoline, diphenoxylate
Antagonists: methylnaltrexone, alvimopan, naloxegol
Two meds for IBS-D and three for IBS-C
IBS-D: eluxadoline, alosetron
IBS-C: linaclotide, lubiprostone, tegaserod
Serotonin antagonist for diarrhea
Alosetron
Alosetron major side effect
Ischemic colitis
One Cl channel inhibitor vs one Cl channel activator
Inhib: crofelemer
Activator: lubiprostone
Major use for crofelemer
Non-infectious diarrhea in HIV pts on ART
Two drug classes for opioid induced constipation
- Peripheral opioid antagonists
2. Cl channel activators
Drug only used for preventing post-op ileus
Alvimopan
Risk of alvimopan
MI’s when using 15+ doses
What receptor do peripheral opioid antagonists work on
Mu
Two drug classes for chronic idiopathic constipation
- Guanylate cyclase C agonsists
2. Cl channel activators
One guanylate cyclase C agonist
Linaclotide
One Cl channel activator
Lubiprostone
One 5HT4 receptor partial agonist
Tegaserod
Four bulk forming agents
- Food
- Psyllium
- Methylcellulose
- Ca polycarbophil
Two stool softeners
- Decussate
2. Mineral oil
Three laxative classes that can cause electrolyte disturbances
- Salines
- Osmotics
- Stimulants
Four osmotics
- Lactulose
- Lacitol
- Polyethylene glycol
- Sorbitol
Drug for liver dz pts with hyperammonemia
Lactulose
Three drugs used for colonoscopy prep
- 3 salines together
- PEG3350
- Na picosulfate
Four stimulants
- Bisacodyl
- Glycerin
- Senna
- Na picosulfate
Senna side effect
Urine discoloration -> Brown/pink/red