10: IBD Pharm and Mechanisms

Question 1

What does PML stand for? (Caused by a4 integrin inhibitors)

Answer 1

Progressive multifocal leukoencephalopathy

Question 2

IL-12 and IL-23 function

Answer 2

Bind receptors on T cells -> induce differentiation and prduction of pro-inflammatory cytokines

Question 3

JAKs (Janus kinases) function

Answer 3

Intracellular enzymes that transmit signals from cytokine interactions on membrane -> influence pro-inflammatory gene transcription and expression

Question 4

Up to what % of T cells in GALT are Tregs?

Answer 4

10%