Extras: Anti-Ulcer and N/V Drugs

Question 1

H2 receptor antagonist rare adverse effect

Answer 1

Blood dyscrasias

Question 2

Cimetidine side effect

Answer 2

Anti-androgen -> gynecomastia in men + galactorrhea in women

Question 3

Rare side effect of PPIs

Answer 3

CDIFF associated diarrhea

Question 4

Best use for Misoprostil/Cytotec/PGE1 analogs

Answer 4

Prevention of NSAID-induced ulcers

Question 5

Which anti-ulcer drug induces abortion?

Answer 5

Misoprostil

Question 6

Side effect of bismuth subsalicylate

Answer 6

Black/dark stools

Question 7

Location of action for each of the six classes of N/V meds

Answer 7

1. 5HT: vagal -> CTZ
2. NK1: vagal & CTZ
3. H1: vestibular
4. D2: CTZ
5. M1: vestibular
6. CB: periportal and central; VC and CTZ

Question 8

Three groups of N/V meds that can be used for all types of N/V

Answer 8

1. 5HT
2. H1
3. D2

Question 9

Biggest side effect with 5HT antagonists for N/V

Answer 9

QT prolongation (dont combine with anti-arrhythmics

Question 10

2 5HT receptor antagonists used for delayed CINV bc they have longer half life’s

Answer 10

1. Granisetron

2. Palonosetron

Question 11

Indication for NK1 receptor antagonists

Answer 11

CINV

Question 12

Ending for NK1 receptor antagonist drugs

Answer 12

-pitant

Question 13

Ending for serotonin receptor antagonists

Answer 13

-setron

Question 14

Side effects for H1 and M1 receptor antagonists

Answer 14

Cholinergic effects -> dry mouth, drowsiness, constipation, urinary retention, blurred vision, decreased BP

Question 15

Name 7 H1 receptor antagonists

Answer 15

1. Diphenhydramine
2. Dimenhydrinate
3. Hydroxyzine
4. Promethazine
5. Meclizine
6. Cyclizine
7. Doxylamine w B6

Question 16

Initial therapy for NVP

Answer 16

Doxylamine with B6

Question 17

Four D2 receptor antagonists

Answer 17

1. Prochlorperazine
2. Olanzapine
3. Metoclopramide
4. Amisupride

Question 18

N/V med thats also anti-psychotic

Answer 18

Olanzapine

Question 19

Drug for GI dysmotility/gastroparesis

Answer 19

Metoclopramide

Question 20

Drug only used for post-op N/V

Answer 20

Amisulpride

Question 21

The only M1 receptor antagonist

Answer 21

Scopolamine

Question 22

Two Cannabinoid receptor agonists

Answer 22

1. Dronabinol

2. Nabilone

Question 23

4 drug regimen for high emetogenic chemo

Answer 23

1. Serotonin antag
2. Neurokinin antag
3. Corticosteroid
4. Dopamine antag