7: Ulcer And GERD Pharm

Question 1

What if youre trying to tx an ulcerative disease with PPIs or H2 antagonists but it has H. Pylori involvement?

Answer 1

It will not heal - those drugs do not tx H. Pylori

Question 2

Two prototypical CYP450 inhibitors that are also GERD drugs

Answer 2

1. Cimetidine

2. Omeprazole

Question 3

Name the five drug classes for treating Ulcers

Answer 3

1. H2 receptor antagonists
2. PPIs
3. Surface acting agents
4. PGE1 analogs
5. Bismuth compounds

Question 4

Which anti-ulcer drug class could hypothetically shut down 100% of acid production and why

Answer 4

PPIs: inhibits the final step in the acid production/releasing pathway