Extra theory Flashcards
cAMP is hydrolyzed by ___
Phosphodiesterase
Which molecule increases the activity of phosphodiesterase?
Insulin
Where is cAMP formed? In response to which hormones (3)
Adenylyl cyclase
→ in response to epinephrine, norepinephrine & glucagon
Is muscle sensitive to glucagon?
No
Function of glycogen extra hepatic tissue?
provide glucose
Function of cAMP
Activation of phosphorylase
Inhibition of glycogen synthase
What is the transporter of long-chain FAs (>12C)
FATP - fatty acid transporter protein
What is the transporter for cholesterol?
NPCL1
- Niemann-Pick-C10like
What is the transporter for cholesterol?
NPCL1
- Niemann-Pick-C10like
Do side chains contribute to alpha helix stability?
Np, because they face outwards
Type of alpha helices of single collagen polypeptides
Left-handed helices (not alpha helix)
Type of alpha helices of 3 collagen polypeptides bundle
Right-handed triple helix
What is transition state analogue?
A drug that binds to and therefore inhibits an enzyme because the drug resembles the transition state of a reaction normally catalyzed by the enzyme.
What is oxidative decarboxylate of pyruvate?
the conversion of pyruvate into acetyl-CoA by the enzyme complex pyruvate dehydrogenase complex.
Where does fructose 2,6-biphosphate come from? How can it be hydrolyzed?
Fructose 2,6-bisphosphate is synthesized from fruc- tose 6-phosphate and ATP by an enzyme called PFK 2 and
=> is hydrolyzed into fruc- tose 6-phosphate and P. by a specific fruc- tose 2,6-bisphosphatase also called FBPase 2
The role and localization of ApoB-100
Localization - VLDL, IDL, LDL
Role
- necessary for the assembly of the individual lipoproteins
- Recognized by the LDL-receptor (receptor-mediated endocytosis)
Bile acids conjugation with cholic acids
Glycocholic acids
Taurocholic acids
