1566 - 1607 (nucleotide metabolism) Flashcards
Identify the missing Compound X
Select one:
a. inosine monophosphate
b. inositol monophosphate
c. indole monophosphate
d. 6-oxopurine monophosphate
e. 6-oxo-5-aminopurine monophosphate
a. inosine monophosphate
Identify the missing Compound X
Select one:
a. adenylosuccinate
b. succinyladenine monophosphate
c. succinylinosine monophosphate
d. 6-oxopurine monophosphate
e. 6-oxo-5-aminopurine monophosphate
a. adenylosuccinate
Identify the missing Compound X
adenosine monophosphate
Find out which cofactors are ‘B’ and ‘C’
B is NAD+, C is NADH + H+
Indentify reactant pair ‘X’ and ‘Y’ in the reaction marked with ‘A’
X is glutamine, Y is glutamate.
Examine the figure below. Identify ‘compound X’.
AMPS is adenylosuccinate, XMP is xanthosine monophosphate.
Inosine monophosphate
Examine the figure below. Identify ‘compound X’.
IMP is inosine monophosphate, XMP is xanthosine monophosphate.
Adenylosuccinate
Examine the figure below. Identify ‘compound X’.
IMP is inosine monophosphate, AMPS is adenlyosuccinate monophosphate.
Xanthosine monophosphate
Select the correct statement below
a. AMP inhibits adenylosuccinate synthase
b. GMP stimulates IMP dehydrogenase
c. GTP inhibits adenylosuccinate synthase
d. ATP inhibits adenylosuccinate synthase
e. GTP promotes IMP dehydrogenase
a. AMP inhibits adenylosuccinate synthase
Select one:
a. ATP promotes IMP dehydrogenase
b. ATP promotes transamidinase
c. AMP inhibits adenylosuccinate synthase
d. GMP inhibits IMP dehydrogenase
e. GTP promotes adenylosuccinate synthetase
a. ATP promotes IMP dehydrogenase
1576 Select the false statement below:
Select one:
a. GMP stimulates IMP dehydrogenase
b. If ATP synthesis is deficient, GTP synthesis is decreased.
c. AMP inhibits adenylosuccinate synthase
d. If GTP synthesis is deficient, ATP synthesis is decreased.
e. GTP stimulates adenylosuccinate synthase
a. GMP stimulates IMP dehydrogenase
Select the correct statement below:
a. GMP inhibits IMP dehydrogenase
b. If ATP synthesis is deficient, GTP synthesis is increased compensatory.
c. GTP stimulates adenylosuccinate lyase
d. If GTP synthesis is deficient, ATP synthesis is increased compensatory.
e. ATP inhibits adenylate kinase
a. GMP inhibits IMP dehydrogenase
Identify ‘compound X’
AMP
Identify ‘compound X’
GMP
Identify ‘enzyme X’.
Thioredoxin reductase
Identify ‘endproduct X’.
2′- Deoxyribonucleoside diphosphate
Indentify ‘Cofactor X’ that is needed for the reaction below:
NADPH + H+
What is the role of the following reaction?
a. Provides deoxyribonucleosi de diphosphates for DNA synthesis and repair.
b. Provides deoxyribonucleosi de diphosphates for DNA repair.
c. Provides deoxyribonucleoside diphosphates for DNA synthesis.
d. Provides deoxyribonucleosi de diphosphates for DNA and RNA synthesis.
e. Provides deoxyribonucleoside diphosphates for DNA and RNA repair.
Provides deoxyribonucleoside diphosphates for DNA synthesis and repair.
Indentify ‘cofactor X’ that is oxidized and then reduced by the enzyme highlighted with red in the following reaction:
Thioredoxin
Indentify ‘cofactor X’ that is oxidized and then reduced by the enzyme highlighted with red in the following reaction:
Thioredoxin
Examine the figure below. Identify the missing enzyme ‘Enzyme X’.
a. Dihydroorotase
b. DHOA synthase
c. DHOA synthetase
d. Carbamoyl dehydratase e. CAA dehydrogenase
a. Dihydroorotase
Examine the figure below. Identify the missing enzyme ‘Enzyme X’.
Orotidylic acid decarboxylase
Examine the figure below. Identify the missing enzyme ‘Enzyme X’.
CTP synthase
Examine the figure below. Identify the missing enzyme ‘Enzyme X’.
Ribonucleotide reductase
Carbamoyl phosphate synthase II (figure below) is located in the
a. cytosol
b. mitochondria
c. endoplasmic reticula
d. peroxisome
e. nucleus
a. cytosol
Select the FALSE statement about the following pathway
Select one:
a. The pathway is located in the mitochondrial matrix
b. The pathway is energetically costly.
c. Several steps of the pathway are catalyzed by multifunctional proteins.
d. The carbamoyl phosphate pool for urea and nucleotide synthesis is separated.
e. Channeling of the intermediates of pyrimidine biosynthesis serves as a facilitator factor.
a. The pathway is located in the mitochondrial matrix
Which compound is a pyrimidine analog that is an alternative substrate of Orotate phosphoribosyltransferase enzyme?
a. 5-fluorouracil
b. 8-Azaguanine
c. 6-Thioguanine
d. mycophenolic acid
5-fluorouracil
Examine the figure below. Identify the missing compound ‘Compound X’.
Carbamoyl phosphate
Examine the figure below. Identify the missing compund ‘Compound X’.
Orotic acid
1595 Select the FALSE statement about the following regulation system:
a. TDP promotes phosphoribosyl pyrophosphate synthesis
b. CTP inhibits carbamoyl aspartic acid synthesis
c. UTP inhibits phosphate synthesis
d. Phosphoribosyl pyrophosphate carbamoyl
synthesis
a. TDP promotes phosphoribosyl pyrophosphate synthesis
Examine the figure below. Which is the factor that directly regulates ‘Reaction A’? CAP is carbamoyl phosphate.
Select one:
a. The level of purine nucleotides.
b. The level of DHOA
c. The level of ATP
d. The level of CTP.
e. The level of TMP.
a. The level of purine nucleotides.
Examine the figure below. Identify the missing ‘Compound X’.
Adenosine
Examine the figure below. Identify the missing ‘Compound X’.
Inosine
Examine the figure below. Identify the missing ‘Compound X’.
Guanosine
Examine the figure below. Identify the missing ‘Compound X’.
Hypoxanthine
Examine the figure below. Identify the missing ‘Compound X’.
Guanine
Examine the figure below. Identify the missing ‘Compound X’.
Xanthine
Examine the figure below. Identify the missing ‘Compound X’.
Uric acid
Examine the figure below. Identify the missing ‘Enzyme X’.
Adenosine deaminase
Examine the figure below. Identify the missing ‘Enzyme X’.
Purine nucleoside phosphorylase
Examine the figure below. Identify the missing ‘Enzyme X’.
Xanthine oxidase
1607 Examine the figure below. Which statment is TRUE about the biosynthesis of purine and pyrimidine nucleotides?
a. ATP stimulates 2’dCTP synthesis
b. ATP inhibits 2’UDP synthesis
c. 2’dTTP exerts a positive feedback for its own synthesis
d. 2’GTP inhibits the synthesis of 2’dADP
a. ATP stimulates 2’dCTP synthesis
