export_nutrition test 3 Flashcards
Dry forage that has lost all carotenoid from oxidation and UV light exposure
Caged birds given grain only
Circumstances causing vitamin A deficiency
Night blindness
Atrophy of epithelial cells
Secretory cells are replaced by stratified keratinized squamos epithelium
Disrupted bone growth and development
Signs of Vitamin A deficiency
Vitamin A
Which vitamin is one of the most potentially toxic nutrients?
Pruritis, hair loss, bone and muscle pain, ataxia, embryo and fetal malformations
Vitamin A toxicity signs
Vitamin E
Organic compounds w/ biological activity and structure similar to that of d-a-tocopherol
d-a-tocopherol
Which form of vitamin E is most active?
8
How many forms of vitamin E are there in nature?
Vegetables and seed oils-good
Animal products-bad
Sources of Vitamin E
- Antioxidant
2. Prevents lipid peroxidation
Functions of Vitamin E
Vitamin E protects fatty acids in the cell membrane from oxidative damage
How are vitamin E and unsaturated fatty acids related?
E
Least potentially toxic vitamin of fat soluble vitamins
INterferes w/ coagulation by antagonizing vitamin K
What happens if there is too much vitamin E?
Se and Vitamin E
Which substances work together to inhibit lipid peroxidation damage?
Se
One of the most potentially toxic nutrients
When soils are high in Se
High Se forage and graiin
WHen can Se toxicity occur?
Dullness, inactivity, emaciation, rough hair coat, hair loss
Sloughing of hooves and erosion of long bone joints in horses and cattle
WHat are signs of Se toxicity?
Testicular degeneration and fetal resorption in rats, Muscular dystrophy in rabbits, encephalomalacia in chicks, steatitis in cats
What are Vitamin E deficiency symptoms not responding to Se supplementation?
Nutritional muscular dystrophy “white muscle disease,” liver edema and necrosis in pigs, severe subQ edema and pancreatic dystrophy in chickens
Deficiency symptoms that respons to either Se or Vitamin E
K1-green plant
K2-bacteria
K3-synthetic
Where do vitamin K1 or phylloquinones come from vs vitamin K2 or menaquinones come from? and K3 or menadione
Green leafy plants
Liver, egg, and some fish meals
Intestinal bacteria can variably supply vitamin K needs
Sources of vitamin K
Co-factor in formation of y-carboxyglutamic acid (GLA) residues proteinases
GLA residues serve as Ca-binding sites needed for proteinase activation
Coagulation proteins synthesized and stored in the liver
Functions of vitamin K
Total body pool is replaced rapidly, hours to days.
Contrast w/ weeks to months of the other fat soluble vitamins
What is different about vitamin K absorption and metabolism compared to other fat soluble vitamins?
Warfarin, Dicumarol, high fish diets for cats, prolonged antibiotic therapy, long term total parenteral nutrition, poultry are susceptible due to short GI tract and fed antimicrobials
Vitamin K deficiency can be caused by?
Dicumarol is produced in spoiled sweet clover hay that cattle ingest and they die from massive hemorrhage
What is hemorrhagic sweet clover disease?
Uncontrolled hemorrhage both resulting from minor wounds and internal bleeding into the gut and body cavity
Signs of vitamin K deficiency
Vitamin B3
Nicotinic acid
Nicotinamide
Other names for niacin
Used in formation of coenzymes
F (niacin)
Plants and other sources of some cereals, legumes, and yeast
Largely in bran of cereals
Tryptophan
Sources of niacin
Negligible
Conversion of tryptophan niacin is ______ in cats
Poor diet and conditions affecting tryptophan-niacin conversion
Why would an animal become niacin deficient?
Dermatitis (pellagra)
Diarrhea
Dementia
Signs of niacin deficiency
Loading test results- nicotinamide amount recovered in urine after an oral load of nicotinamide indicates deficiency
How can a niacin deficiency be diagnosed?
Formation of flavocoenzymes (FAD and FMN) which are used for catabolism of glucose, fatty acids, ketone bodies, and AA, intracellular respiratory system of all cells, reductive biosynthesis
F (riboflavin) or B2
Plants- green veggies, but not cereals.
Animals- milk, eggs, organ meats
Sources of riboflavin
UV light
What inactivates riboflavin?
When grain is main source of food
Causes of riboflavin deficiency
Reduced growth rate, stunting
Seborrheic dermatitis, hair loss
Stomatitis, glossitis, cheilosis, corneal vascularization and eye pain, anemia, neuropathy
Signs of riboflavin deficiency
Enzyme stimulation test-
How can you diagnose riboflavin deficiency?
Cofactor for catabolism of carbs and AA metabolism for energy production
Nerve conduction function
F (thiamin/B1)
Meats, especially pork and organs, egg yolk
green portions of plants, whole cereal grains,
Thiamin sources
Thiamin is destroyed by high temperatures
Thiaminases destroy thiamin in raw fish, bracken fern, and horse tail
Coccidiostat, amprolium
Low dietary levels
Dietary factors that can cause thiamin deficiency
reduced FI, body weight loss, neurological changes
Thiamin deficiency signs in cats and dogs
Incoordination to the point of falling, bradycardia due to cardiac irregularity
Signs of thiamin deficiency in horses
Neurological changes
Signs of thiamin deficiency in cattle and sheep
Enzyme stimulation test- erythrocyte transketolase
How is thiamin deficiency diagnosed?
Green leafy veggies, lima beans, citrus fruits, meats
Sources of folate