Examen 1 neuro parties plus difficiles Flashcards

1
Q

enzyme dégradation acétylcholine

A

acétylcholinestérase
butyrylcholinestérase

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2
Q

enzyme assemblage acétylcholine

A

choline acétyltransférase

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3
Q

effets acétylcholine récepteur muscarinique

A

DIC -
VD hypotension
BC
myosis
augmentation péristaltisme
contraction muscle + relâchement sphincter
augmentation sécrétions

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4
Q

enzyme noradrénaline

A

tyrosine hydroxylase

dopa décarboxylase

DBH

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5
Q

NAD

A

COMT
MAOa = sérotonine, NAD
MAOb = dopamine

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6
Q

transporteurs dopamine

A

DAT
NET
VMAT2

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7
Q

récepteurs D1 et D2

A

D1:
hypothalamus
substance noire
cortex frontal

D2:
striatum
substance noire
cortex préfrontal

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8
Q

zones dopamine

A

mésocortical
mésolimbique
nigrostriale
tubéro-infundibulaire

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9
Q

zone mésocortical

A

fonction cognitive
récompense, motivation, émotion
contrôle impulsivité
ADHD
psychose

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10
Q

zone mésolimbique

A

récompense
psychose
addiction
schizophrénie
déficit apprentissage

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11
Q

zone nigrostriatale

A

motricité mouvement
Parkinson

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12
Q

zone tubéro-infundibulaire

A

sécrétion prolactine
glande pituitaire

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13
Q

enzyme dégradation sérotonine

A

MAOa
tryptophane

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14
Q

médicament sérotonine

A

triptan = migraine 5HT1 = pré ago
sétron = nausée 5HT3 = post antago
dépression = inhibiteur transport SERT

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15
Q

enzyme glutamate

A

transaminase
glutaminase

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16
Q

récepteurs glutamate

A

NMDA
post excitatrice
MG intra = important
glycine : co-agoniste

17
Q

médicament glutamate

A

antago NMDA pour
alzheimer
hyperalgésie (mg renforce)

18
Q

enzyme GABA

A

GAD
GABA transaminase

19
Q

médicament GABA

A

agoniste GABA pour
anxiété
trouble sommeil

20
Q

GABAa vs GABAb

A

ionique
ligand-dépendant
inhibition précoce

métabotropique
inhibition tardive

21
Q

médicament histamine

A

antagoniste H1 = allergie
antagoniste H2 = ulcère

22
Q

récepteurs H1

A

activatrice
muscle lisse
cellule endo
SNC

23
Q

fixation récepteur opioïde

A

Mu
diminution GABA libéré
levée inhibition exercée par GABA sur dopamine
augmentation dopamine

24
Q

fonctions neuropeptides

A

régulation
prise alimentaire
fonctionnement SN défense immunitaire

25
Q

CGRP

A

rôle essentiel crise douloureuse
migraine avec P

26
Q

récepteurs adaptation

A

rapide/phasique = maximal mais brève toucher. pression odorat

lente/tonique : douleur, position corps, composition chimique sang