Exam 6: Endocrine 2 Flashcards
Melatonin
Source: Pineal Gland
Target Organs & Tissues: Brain
Function: Sleep, may influence mood and sexual maturation
Thymopoetin, Thymosin, Thymulin
Source: Thymus
Target Organs & Tissues: Immune Cells ( T Lymphocytes)
Function: Stimulate T Lymphocytes development and activity
Thyroxine (T4) & Triiodythyonine (T3)
Source: Thyroid Gland
Target Organs & Tissues:Most Tissues
Function: Elevate metabolic rate & heat production, increase respiratory rate, heart rate, strength of heartbeat
*Requires iodine to be produced which is found in goods and iodized salt
Calcitonin
Source: Thyroid Gland
Target Organs & Tissues: Bone
Function: lowers blood calcium by accelerating storage in bones (calcium is important for blood clotting, muscle contraction, and holding cells together)
Parathyroid Hormone (PTH)
Source: Parathyroid Gland
Target Organs & Tissues: Bones, Kidneys, and Small Intestine
Function: Raises blood calcium by stimulating bone reabsorbtion and inhibiting deposition, reducing urinary calcium , and enhancing calcitriol synthesis
Epinephrine, Norepinephrine, Dopamine
Source: Adrenal Medulla (Adrenal Gland)
Target Organs & Tissues: Most Tissues
Function: Promote alertness, mobilize organic fuels, raise metabolic rate, stimulate circulation and respiration, increase blood glucose levels, inhibit insulin secretion and glucose uptake by insulin dependent organs (spairing glucose for brain)
Aldosterone
Source: Adrenal Cortex (Zona Gomerulosa)
Target Organs & Tissues: Kidney
Function: Promotes sodium and water retention AND potassium excretion; maintains blood pressure and volume
Cortisol and Corticosterone
Source: Adrenal Cortex (Zona Fasciculata and Zona Reticularis)
Additional Info: Both are glucocorticoids
Target Organs & Tissues: Most Tissue
Function: Stimulate fat and protein catabolism, gluconeogenisis, stress resistance & tissue repair
Dehydropiandrosterone (DHEA)
Source: Adrenal Cortex (Zona Fasciculata and Zona Reticularis)
Additional Info: Is an Androgen
Target Organs & Tissues: Bone, muscle, integument, brain, many other tissues.
Function: Precursor to testosterone, indirectly promotes growth of bones, public and axillary hair, apocrine glands, and fetal male reproductive tract, stimulates libido
Glucagon
Source: Pancreas (Alpha Cells)
Target Organs & Tissues: Liver
Function: Stimulates amino acid reabsorbtion, gluconeogensis, glycogen and fat breakdown, raises blood glucose and fatty acid levels
Insulin
Source: Pancreas (Beta Cells)
Target Organs & Tissues: Most tissues
Function: stimulates glucose and amino acid uptake; lowers blood glucose level, promotes glycogen, fat, and protein synthesis
Somatostatin
Source: Pancreas (Delta Cells)
Target Organs & Tissues: Stomach, intestines, pancreatic islet cells
Function: Modulates digestion, nutrient absorbtion, and glucagon and insulin secretion
Gastrin
Source: Pancreas (PP Cells)
Target Organs & Tissues: Stomach
Function: Stimulates acid secretion and gastric motility.
Estradiol
Source: Ovaries
Target Organs & Tissues: Many tissues
Function: stimulates female reproductive development and adolscent growth, regulates menstrual cycle and pregnancy; prepares mammary glands for lactation
Progesterone
Source: Ovaries/ Placenta
Target Organs & Tissues: Uterus, Mammary Glands
Function: Regulates menstrual cycles and pregnancy; prepares mammary glands for lactation
Inhibin
Source: Ovaries
Target Organs & Tissues: Anterior Pituitary
Function: inhibits FSH secretion
Testosterone
Source: Testes
Target Organs & Tissues: Many tissues
Function: stimulates fetal and adolscent reproductive development, musculoskeletal growth, sperm production, and libido
Inhibin
Source: Testes
Target Organs & Tissues: Anterior Pituitary
Function: inhibits FSH secretion
Chloecalciferol
Source: skin
Target Organs & Tissues:
Function: precursor of calctriol
Calcidiol
Source: Liver
Target Organs & Tissues:
Function: precursor of calctriol
Angiotensinogen
Source: Liver
Target Organs & Tissues:
Function: precursor of angiotenin II
Erythropoetin
Source: Liver and Kidney
Target Organs & Tissues: Red Bone Marrow
Function: promotes red blood cell production, increases oxygen- carrying capacity of blood
Hepcidin
Source: Liver
Target Organs & Tissues: Small Intestine/ Liver
Function: regulates plasma iron level
insulin-like growth factor I
Source: Liver
Target Organs & Tissues: many tissues
Function: prolongs and mediates action of growth hormone
Angiotensin I
Source: Kidneys
Target Organs & Tissues:
Function: precursoe of angiotensin II, a vasoconstrictor
Calcitriol
Source: Kidneys
Target Organs & Tissues: small intestine
Function: increases blood calcium level mainly by promoting intestinal absorbtion of calcium
Natruretic Peptides (NP)
Source: Heart
Target Organs & Tissues: Kidney
Function: lowers blood volume and pressure by promoting sodium and water loss
Chloecytsokinin
Source: Stomach & Small Intestine
Target Organs & Tissues: Gallbladder, brain
Function: bile release, apetite supression
Gastrin
Source: Stomach & Small Intesntine
Target Organs & Tissues: Stomach
Function: Stimulates acid secretion
Ghrelin
Source: Stomach & Small Intestine
Target Organs & Tissues: Brain
Function: Stimulates hunger, initiates feeding
Peptide YY
Source: Stomach & Small Intestine
Target Organs & Tissues: Brain
Function: produces sense of satiety, terminates feeding
Leptin
Source: adipose tissue
Target Organs & Tissues: Brain
Function: limits appetite over long term
Osteocalcin
Source: osseous tissue
Target Organs & Tissues: pancreas, adipose tissue
Function: stimulates pancreatic beta cells to multiply, increases insulin secretion, enhances insulin sensitivity of various tissues, and reduces fat deposition
Lipocalin 2
Source: osseous tissue
Target Organs & Tissues: pancreatic beta cells
Function: promotes insulin secretion and action
Steroid Hormones
End in -iol or -one; example: calcitriol, aldosterone, corticosterone