Exam 5 - Tuberculosis Pastakia Flashcards
“infection eliminated with INNATE immune response”; what are the results for the following?
TST
IGRA
Culture
Sputum Smear
Infectious
Symptoms
Preferred Treatment
TST -
IGRA -
Culture -
Sputum Smear -
Infectious: no
Symptoms: none
Preferred Treatment: none
“infection eliminated with ACQUIRED immune response”; what are the results for the following?
TST
IGRA
Culture
Sputum Smear
Infectious
Symptoms
Preferred Treatment
TST +
IGRA +
Culture -
Sputum Smear -
Infectious: no
Symptoms: none
Preferred Treatment: none
“Latent TB infection”; what are the results for the following?
TST
IGRA
Culture
Sputum Smear
Infectious
Symptoms
Preferred Treatment
TST +
IGRA +
Culture -
Sputum Smear -
Infectious: no
Symptoms: none
Preferred Treatment: preventive therapy
“Subclinical TB disease”; what are the results for the following?
TST
IGRA
Culture
Sputum Smear
Infectious
Symptoms
Preferred Treatment
TST +
IGRA +
Culture: intermittently +
Sputum Smear: usually -
Infectious: sporadically
Symptoms: mild or none
Preferred Treatment: multidrug therapy
“active TB disease”; what are the results for the following?
TST
IGRA
Culture
Sputum Smear
Infectious
Symptoms
Preferred Treatment
TST: usually +
IGRA: usually +
Culture +
Sputum Smear + or -
Infectious: yes
Symptoms: mild to severe
Preferred Treatment: multidrug therapy
which LTBI medication would you typically want to avoid or be cautious with in pts living with HIV?
rifampin (and derivatives)
TB strains that are sensitive to the standard first-line agents
a. drug susceptible TB
b. monoresistant TB
c. polyresistant TB
d. multidrug resistant (MDR) TB
e. extensively drug-resistant (XDR) TB
a. drug susceptible TB
TB strains that are sensitive to just one anti-TB drug
a. drug susceptible TB
b. monoresistant TB
c. polyresistant TB
d. multidrug resistant (MDR) TB
e. extensively drug-resistant (XDR) TB
b. monoresistant TB
TB strains that are resistant to more than one anti-TB drug but not INH and RIF
a. drug susceptible TB
b. monoresistant TB
c. polyresistant TB
d. multidrug resistant (MDR) TB
e. extensively drug-resistant (XDR) TB
c. polyresistant TB
TB strains that are resistant to RIF and INH
a. drug susceptible TB
b. monoresistant TB
c. polyresistant TB
d. multidrug resistant (MDR) TB
e. extensively drug-resistant (XDR) TB
d. multidrug resistant (MDR) TB
TB strains that are resistant to RIF and INH + at least one injectable agent (amikacin, kanamycin, or capreomycin) + any of the fluoroquinolones.
a. drug susceptible TB
b. monoresistant TB
c. polyresistant TB
d. multidrug resistant (MDR) TB
e. extensively drug-resistant (XDR) TB
e. extensively drug-resistant (XDR) TB
how is resistance in TB slightly different than other bacteria? (slide 29)
the bacteria that causes TB can develop resistance to drugs through spontaneous mutations in its DNA (there is also acquired resistance)
tx of drug susceptible TB: 6 month regimen intensive phase (4 drugs)
rifampin 600 mg
isoniazid 300 mg
pyrazinamide 1000-2000 mg
ethambutol 800-1600 mg
once/day x 8 weeks
tx of drug susceptible TB: 6 month regimen continuation phase (2 drugs)
rifampin 600 mg
isoniazid 300 mg
once/day x 18 weeks
tx of drug susceptible TB: 4 month regimen intensive phase (4 drugs)
rifapentine 1200 mg
isoniazid 300 mg
moxifloxacin 400 mg
pyrazinamide 1000-2000 mg
once/day x 8 weeks
tx of drug susceptible TB: 4 month regimen continuation phase (3 drugs)
rifapentine 1200 mg
isoniazid 300 mg
moxifloxacin 400 mg
once/day x 9 weeks
spontaneous mutations develop as bacilli proliferate to ____
a. 10^3
b. 10^6
c. 10^8
d. 10^10
c. 10^8
