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PHRM 865 Therapeutics > Exam 2 - Penicillins Erdman > Flashcards

Exam 2 - Penicillins Erdman Flashcards

1
Q

which beta-lactams are NOT primarily eliminated unchanged by kidneys? (4 of them)

A

nafcillin
oxacillin
ceftriaxone
cefoperazone

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2
Q

which beta lactam does NOT have cross-allerginicity?

A

aztreonam

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3
Q

3 MOR of penicillins

A
  1. production of beta lactamase enzymes
  2. alteration in structure of PBPs
  3. alteration of outer memb porin proteins
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4
Q

4 natural penicllins

A

aq penicillin G
benzathine penicillin G
procaine penicillin G
phenoxylmethyl penicllin (penicillin VK)

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5
Q

IV formulation

a. aq penicillin G
b. benzathine penicillin G
c. procaine penicillin G
d. phenoxylmethyl penicllin (penicillin VK)

A

a. aq penicillin G

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6
Q

IM formulation (2 of them)

a. aq penicillin G
b. benzathine penicillin G
c. procaine penicillin G
d. phenoxylmethyl penicllin (penicillin VK)

A

d. phenoxylmethyl penicillin (penicillin VK)

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7
Q

oral formulation

a. aq penicillin G
b. benzathine penicillin G
c. procaine penicillin G
d. phenoxylmethyl penicllin (penicillin VK)

A

d. phenoxylmethyl penicllin (penicillin VK)

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8
Q

What is the primary mechanism of action of penicillins?

a. Inhibiting protein synthesis
b. Inhibiting cell wall synthesis
c. Inhibiting DNA replication
d. Inhibiting RNA synthesis

A

b. Inhibiting cell wall synthesis

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9
Q

What is the primary route of elimination for most penicillins?

a. Hepatic
b. Renal
c. Biliary
d. Pulmonary

A

b. Renal

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10
Q

Which penicillin is known for its activity against Pseudomonas aeruginosa?

a. Amoxicillin
b. Piperacillin
c. Penicillin VK
d. Nafcillin

A

b. Piperacillin

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11
Q

Which penicillin is primarily eliminated by the liver?

a. Amoxicillin
b. Nafcillin
c. Penicillin G
d. Piperacillin

A

b. Nafcillin

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12
Q

Which penicillin is most likely to cause interstitial nephritis?

a. Methicillin
b. Amoxicillin
c. Piperacillin
d. Ticarcillin

A

a. Methicillin (or nafcillin)

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13
Q

Which penicillin is used for the treatment of syphilis?

a. Amoxicillin
b. Penicillin G
c. Nafcillin
d. Piperacillin

A

b. Penicillin G

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14
Q

What is the primary pharmacodynamic property of penicillins?

a. Concentration-dependent killing
b. Time-dependent killing
c. Post-antibiotic effect
d. Synergistic effect

A

b. Time-dependent killing

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15
Q

Which penicillin is effective against methicillin-susceptible Staphylococcus aureus (MSSA)?

a. Amoxicillin
b. Nafcillin
c. Penicillin VK
d. Piperacillin

A

b. Nafcillin

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16
Q
A

PHRM 865 Therapeutics (8 decks)

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