Exam 4 - Antivirals Med Chem 1 Stahelin (not done) Flashcards
commonly causes oral herpes
a. HSV-1
b. HSV-2
c. VZV
d. CMV
a. HSV-1
commonly causes genital herpes
a. HSV-1
b. HSV-2
c. VZV
d. CMV
b. HSV-2
causes chickenpox and shingles
a. HSV-1
b. HSV-2
c. VZV
d. CMV
c. VZV (varicella zoster virus)
common viral cause of cogenital disease
a. HSV-1
b. HSV-2
c. VZV
d. CMV
d. CMV (cytomegalovirus)
which of the following is FALSE about acyclovir?
a. acts a chain terminator
b. is not incorporated into DNA
c. competitive inhibitor of viral DNA polymerase
d. requires 3 phosphorylation events
b. is not incorporated into DNA
which of the following is TRUE about acyclovir?
a. prodrug of penciclovir
b. acyclic adenosine derivative
c. resistance is due to mutations in thymidine kinase or DNA polymerase
d. increased activity against CMV
e. requires 4 phosphorylation events
c. resistance is due to mutations in thymidine kinase or DNA polymerase
(a. is famciclovir; b. is acyclic guanosine; d. is decreased; e. is 3)
which of the following is FALSE about valacyclovir?
a. prodrug of acyclovir
b. transported by intestinal AA transporters
c. L-valyl ester of acyclovir
d. decreased efficacy compared to acyclovir
d. decreased efficacy compared to acyclovir
(increased)
prodrug of penciclovir
famciclovir
conversion of famciclovir to penciclovir is by _____ _____ _____
first pass metabolism
_____ _____ mutants confer cross-resistance to penciclovir and acyclovir
viral kinase
which of the two is NOT an obligate DNA chain terminator?
a. acyclovir
b. penciclovir
b. penciclovir
penciclovir route of administration
topical
famciclovir route of administration
oral
clinical uses of oral famciclovir (2)
-primary and recurrent genital herpes
-acute herpes zoster
clinical use of penciclovir
recurrent herpes labialis
used for recurrent herpes labialis
a. oral famciclovir
b. oral penciclovir
c. topical famciclovir
d. topical penciclovir
d. topical penciclovir
penciclovir MOA (3 things)
-activated by viral and cellular kinases
-comp inhibitor of viral DNA pol
-does NOT cause immediate chain termination
ganciclovir has similar structure and MOA as
a. acyclovir
b. valacyclovir
c. penciclovir
d. foscarnet
c. penciclovir
T or F: ganciclovir has more severe toxicity than acyclovir
T
resistance is due to mutations in CMV kinase (UL97 gene) or CMV DNA pol (UL54)
a. acyclovir
b. ganciclovir
c. famciclovir
d. foscarnet
b. ganciclovir
T or F: penciclovir is 100 times more active against CMV than ganciclovir
F (ganciclovir is 100 times more active than penciclovir)
used to treat CMV retinitis in AIDS pts (3 answers)
a. valganciclovir
b. valacyclovir
c. foscarnet
d. penciclovir
e. ganciclovir
a, c, e
foscarnet binding site
pyrophosphate binding site of viral DNA polymerase
valganciclovir is a prodrug of _______
a. acyclovir
b. ganciclovir
c. famciclovir
d. foscarnet
b. ganciclovir
foscarnet route of administration
IV
foscarnet clinical use
CMV retinitis
resistance for foscarnet
mutations in DNA pol or HIV RT
cidofovir is an acyclic nucleoside phosphonate analog of ________
a. adenosine
b. cytosine
c. guanosine
d. thymine
b. cytosine
which of the following is TRUE about cidofovir?
a. analog of adenosine
b. competitive inhibitor and chain terminator
c. used for hep B virus
d. AE of myelosuppression
b. competitive inhibitor and chain terminator
(a. is cytosine; c. is CMV retinitis; d. is dose-dependent nephrotoxicity)
which drug’s MOA involves inhibiting the terminase complex?
a. ganciclovir
b. foscarnet
c. cidofovir
d. letermovir
d. letermovir
newest anti-herpes virus drug
letermovir
herpes virus DNA replication is through _______ _______ mechanism
rolling circle
the influenza virus is a _______ stranded RNA virus
a. positive
b. negative
c. neutral
b. negative
which of the following is TRUE about influenza?
a. 4 types: A, B, C, D
b. A widely circulates only in humans
c. B and C are found only in animals
d. vaccines protect against A and B
d. vaccines protect against A and B
