Exam 4 - Lecture 3 Flashcards
Anything that sends electrons towards a positive electrode will
Give a positive reading/positive deflection
If we have depolarization in one direction causing a negative deflection, repolarization in the same direction would cause
Positive deflection
If we have depolarization in one direction causing a negative deflection, repolarization in the same direction would cause
Positive deflection
Phase 4 of ventricle muscle is very ____
Slightly sloped.
Phase 4 of SA node is also called
Diastolic depolarization or phase 4 depolarization
Phase 0 of SA node
Upward stroke up action potential, not as sloped as most AP.
In the nodal areas, phase 0 is ______ channels.
Slow L-type Ca++ channels.
Slower to open, slower to close.
Duration/slope of phase 0 is very important because
Determines how fast the action potentials travel throughout the heart.
If it’s super fast, everything else is super fast from sodium traveling through gap junctions
Phase 3 of nodal areas
L-type closing, VG-K re-opening to set the cell
Definite phases of nodal areas
4, 0 and 3.
Some textbooks will say there is a 2nd phase.
There is not a 1st phase at all.
AV node VRm and slope and threshold compared to SA node , and why?
Not as leaky to sodium and calcium in phase 4.
VRm is more negative than SA node, and less slope.
Thats why it’s slower if it’s the pacemaker.
HCN channels in the heart are found where?
Most in the SA
A lot but less in AV
Ventricles there’s hardly any, but they are there.
Real deep interior ventricular APs are
Pretty long, longer plateau phase
Repolarization is set quicker for epicardium than
Subendocardium
Are atrials pumping against high or low resistance?
Low
Atria APs are compared as
In between a fast and slow AP
SA node HR and how often does it generate an AP?
72 bpm; every 0.83 seconds
If we took all of the nervous influences away from SA node, it would generate a heart rate of ____.
If we add SNS activity ONLY:
110 bpm; 120bpm (up by 10bpm)
What has a greater affect on HR, SNS or PNS (vagal)
PNS is much stronger effect
Secondary pacemaker is ___ and it generates spontaneous APs at __________ per minute.
AV node; 40-60bpm
Other pacemaker system of heart not SA or AV node, and it will spontaneously generate APs at ____ per minute.
purkinje fibers which is conduction system of ventricles, and it will beat at 15-30bpm.
What is the conduction system of the heart specifically for other than the obvious generating APs for heart beat?
Coordinated timing of all of the muscle mass. Needs to be an orderly process for the signals that each take a defined amount of time.
Conduction system in right atria are called
3 internodal pathways (in between SA and AV node)
Anterior
middle
posterior
Anterior internodal pathway is and its also called?
a bundle or collection of tissue that will conduct signals to left atrial pathway
Interatria bundle or bachman’s bundle
Time for AP to go from SA to AV node via internodal pathway
.03 seconds
3/100ths of a second
Time for AP to go from node to right atrial muscle to depolarize
0.07
Time for AP to go from node to left atrial muscle to depolarize
0.09
How long is the duration of the P-wave and what is it
0.09
time for all of the atria to depolarize
Why does it take longer for AP to reach outside of left atria?
no specialized conduction tissue, has to go through myofibrils
Time for a perfectly healthy heart for an AP to go from SA to the entire heart including ventricles?
0.22 seconds
Delay at AV node that causes holdup is due to
Delays so the atrials can contract and fill ventricles before AP goes to ventricles and contracts them to eject blood
If there are extra action potentials, what can fix that?
The delay of the AV node can help reset.
AV node acts as a filter
Why is there a delay in AV node? (physically)
fatty and cells don’t have many gap junctions, causing AP to take longer to travel.
Delay time of AV node
0.12 seconds
Delay in bundle of HIS is how long
.01
Total time for AP to get from SA node to each of main bundle branches is
0.16 seconds
.03 internodal
.12 delay in AV node
.01 delay in bundle of HIS
After an AP from SA node (P-wave), how long will it take QRS to start?
0.16 seconds