exam 4

Question 1

name receptors and their effects

Answer 1

mu- GI and resp
delta- tolerance
kappa- GI

Question 2

list the order of histamine release from highest to lowest

Answer 2

Meperidine
Codeine
Morphine
Hydrocodone
Oxycodone
Hydromorphone
Fentanyl

Question 3

list opioid agonists

Answer 3

Codeine
Hydrocodone–> morphone
Oxycodone–> morphone
Fentanyl
Meperidine
Methone

Question 4

codeine, hydrocodone and oxycodone use what enzyme to be broken down into their active forms?

Answer 4

CYP2D6

Question 5

codeine has DI with what?

Answer 5

CYP2D6 inhibitors

*side note- avoid it in peds

Question 6

avoid morphine in what?

Answer 6

renal dysfunction

Question 7

this drug has a black box warning for CYP3A4 inhibitors

Answer 7

oxycodone

Question 8

this drug is used for shivering and has side effects of serotonin syndrome and seizures

Answer 8

meperidine

Question 9

what is methadone used for?

Answer 9

opioid addiction

Question 10

3 ADRs of methadone

Answer 10

wide 1/2 life
QT prolongation
many enzyme DIs

Question 11

list 2 weak agonists/ reuptake inhibitors

Answer 11

tramadol and tapentadol

Question 12

list a mixed agonist- antagonist

Answer 12

buprenorphine

Question 13

buprenorphine MOA

Answer 13

mu agonist
kappa antagonist

Question 14

use of buprenorphine

Answer 14

opioid withdrawl

Question 15

list 2 antagonist

Answer 15

naloxone
methylnaltrexone

Question 16

this drug for chronic anemia has a block box warning for death, MI, stroke, clot

Answer 16

EPOs

Question 17

what schedule are these
heroin, weed, LSD

Answer 17

schedule 1

Question 18

what schedule are these
cocaine
codeine, cocaine, oxycodone, hydrocodone, amphetamine

Answer 18

schedule 2

Question 19

what schedule is this
buprenorphine

Answer 19

schedule 3

Question 20

what scheule are lams and pams

Answer 20

scheudle 4

Question 21

local anesthetics MOA

Answer 21

blocks Na+ channels

Question 22

order of impact of local anesthetics

Answer 22

sympathetic
pain
temp
touch
motor

Question 23

all local anesthetics are vasodilators except ________

Answer 23

cocaine

Question 24

name a nondepolarizing neuromuscular block

Answer 24

roc

Question 25

name a depolarizing neuromusclular blocker

Answer 25

succinyllcholine

Question 26

this muscle relaxant facilitates GABAa

Answer 26

diazepam

Question 27

this muscle relaxant facilitates GABAb

Answer 27

baclofen

Question 28

this muscle relaxant is an alpha 2 agonist

Answer 28

tizanide

Question 29

DI of tizanide

Answer 29

levels increase in response to CYP1A2

Question 30

this muscle relaxant works by interference with Ca2+ and ryanodine receptors

Answer 30

dantrolene

Question 31

this muscle relaxant acts on the brainstem and interferes with polysynaptic reflexes

Answer 31

cyclobenzaprine