abx Flashcards
this type of drug inhibits growth and replication of bacteria
bacteriostatic
this type of drug kills bacteria
bactericidal
name off bacteriostatic drugs
Clarithromycin
Erythromycin
Trimethoprim
Sulfamethoxazole
Chloraamphenicol
Tetracyclines
name off bactericidal drugs
Vancomycin
Fluoroquinolones
PCN
Aminoglycosides
Cephalosporins
Metronidazole
name off 3 classes of cell wall inhibitors
beta lactams
glycopeptides
lipopeptides
beta lactam MOA
binds PBPs to inhibit cell wall synthesis
are beta lactams bacteriostatic or bacteriocidal?
bactericidal
what beta-lactam/ beta-lactamase inhibitors cover pseudomonas?
piperacillin/ tazobactam and ticarcillin/ clav
what are 4 major examples of beta- lactams
PCNs
cephalosporins
carbapenems
monobactem
list 3 subtypes of PCNs
natural
aminopenicillins
anti-staph/ penicillinase resistant
natural PCNs include…
PCN G and PCN VK
what 2 conditions do natural PCNs target?
syphilis and strep pharyngitis
what are 2 examples of aminopenicillins?
amoxicillin and ampicillin
aminopenicillins require the addition of what to be bactericidal against against enterococci?
aminoglycosides
list 3 examples of anti-staph/ penicillinase-resistant abx
nafcillin, oxacillin, methicillin
list 1st gen cephalosporins
cefazolin, cephalexin, cefadroxil
should yo use 1st gen cephalosporins for MSSA in the CNS?
NO
list 2nd gen cephalosporins
cefuroxime- respiratory
cefoxitin and cefotetan- enteric
2nd gen cephalosporin that targets h flu
cefuroxime
2nd gen cephalosporin that is used for abd surgeries and prophylaxis
cefoxitin and cefotetan
3rd generation cephalosporins
ceftriaxone
cefpodoxime
cefixime
cefdinir
ceftazidine
cefotaxime
what 3rd gen cephalosporin is the only one that covers pseudomonas?
ceftazidime
list ceftriaxone and ceftazidime txs
ceftriaxone- lyme disease, gonorrhea, meningitis
ceftazidime- nosocomial infections, febrile neutropenia
what generation cephalosporins penetrate the CNS?
3rd and 4th gens
list a 4th gen cephalosporin
cefepime
does cefepime cover pseudomonas?
yes
list a 5th gen cephalosporin
ceftaroline
list 2 cephalosporin combinations
ceftolozane-tazobactam
ceftazidime-avibactam
ceftolozane-tazobactam coverage
ESBL and pseudomonas
ceftazidime- avibactam coverage
CRE
what carbapenems have IV pseudomonas coverage?
imipenem
meropenem
doripenem
list an example of a monobactam
aztreonam
do monobactams have G+ coverage
NO, NO G+ COVERAGE
these two beta lactams have no need for renal adjustment
nafcillin
ceftriaxone
name an example of a glycopeptide
vancomycin
ADRs of vancomycin
red man syndrome
nephrotoxicity
ototoxicity
glycopeptide MOA
inhibits cross-linking of linear peptidoglycans
is vancomycin bactericidal or bacteriostatic?
bactericidal
list an example of lipopeptides
daptomycin