Exam 3: Novel Therapeutic Approaches

Question 1

The concept that drugs circulate the bloodstream and can reach all cells of the body?

Answer 1

Targeted Drug Therapy

Question 2

What is the major concept behind Targeted Drug Therapy?

Answer 2

Drugs will only bind to and inhibit one protein that is expressed in some cells but not others, thus saving healthy cells

Question 3

What is the purpose of Oncolytic Viruses?

Answer 3

genetically modified viruses to kill cancer cells but not normal cells

Question 4

What are some examples that would improve Bacterial Therapy through modifications?

Answer 4

1. Modified to produce cancer therapeutics so they are apart of the targeted drug delivery system
2. Modified with magnetic nanoparticles so scientists gan guide the to and into tumors

Question 5

What is CD47?

Answer 5

A protein hat is expressed on the surface of tumor cells

Question 6

Why aren’t tumors recognized by the immune system?

Answer 6

hey present a high level of proteins that send a don’t eat me signal

Question 7

How does Anti-CD47 function in reference to treating cancer?

Answer 7

it can block the signals given off by the CD47 protein, thus turning the macrophage ( which usually supports tumor growth) against the cancer

Question 8

What is the main concept of Adaptive Therapy?

Answer 8

Focus on managing Cancer rather than eliminating it by using a low dose of drugs.

Question 9

What is the concept of using low doses of drugs in Adaptive Therapy?

Answer 9

To maintain a small population of non-resistant cancer cells that outcompete the resistant cells

Question 10

What are the goals of adaptive Therapy?

Answer 10

Manipulate the environment of a tumor to reduce the selective advantage of cancer mutations